Bacillus anthracis Antibodies - Overview Press Release

10/15/2001

BIODESIGN International recently introduced several Bacillus anthracis antibodies. Anthrax toxin plays a major role in the pathogenesis of anthrax. Virulent strains of Bacillus anthracis produce a complex exotoxin with 3 distinct antigenic components: the edema factor (EF), the protective antigen or binding domain (PA), and the lethal factor (LF).

Monoclonals to Bacillus anthracis protective antigen (PA) include clone C3, which is an IgG1 isotype and is purified by Protein A chromatography. Clones BAP0101, BAP0102, BAP0103 and BAP0104 are IgG2b isotype and are purified by Protein G chromatography. All Monoclonals to Bacillus anthracis PA do not cross react with lethal factor antigen of B. anthracis, Y. pestis, F. tularensis or Toxoplasma gondii. Antibody pair recommendations for use as capture and detection antibodies are clone BAP0103 and clone BAP0102.

Monoclonals to Bacillus anthracis lethal factor (LF) include clones BAL0105 and BAL0106. These clones are IgG1 isotype and are purified by Protein G chromatography. These clones are recommended for use as an antibody pair for sandwich immunoassays.

All products are for research use only. Not for use in diagnostic procedures.