Apolipoprotein E2, E3, E4 - Overview Press Release

1/15/2002

BIODESIGN International has introduced three recombinant apolipoproteins, E2, E3 and E4. Apolipoprotein E (Apo E) is a ligand for the low density lipoprotein (LDL) receptor and recent research studies have shown that it is an important factor in nerve degeneration and regeneration. Since Apo E continues to be studied for its roles in neuron function and disease, BIODESIGN is pleased to offer these recombinants for use in various research studies. Each Apo E isoform retains full biological activity, enabling researchers to study the interactions of Apo E with other proteins such as beta-amyloid, tau and the LDL receptor.

Each apolipoprotein is produced by baculovirus-mediated expression in Spodoptera frugiperda cells. They are expressed and purified (by affinity chromatography) in their native conformation. Each is provided in 0.7 M ammonium bicarbonate buffer in a 50 ug vial and stored at –20 to –80oC.

BIODESIGN also offers numerous native Apolipoprotein E proteins and antibodies to Human, Hamster, Mouse, and Rabbit Apo E.

Visit the BIODESIGN International web site at www.biodesign.com and click on the link to the Apolipoprotein Product Line or use the Product Search Button to find a specific antibody or protein. Alternatively, call our toll free number 888-530-0140 or telephone 207-283-6500 to request additional product information.

All products are for research use only. Not for use in diagnostic procedures.