北京义翘神州
Antibodies for Influenza Antigen Test

流感病毒核蛋白(NP)在病毒复制和宿主适应中起关键作用,属于结构蛋白。针对NP蛋白的抗体通常用于各种流感病毒的免疫检测中,如ELISA、FLA、荧光抗体检测等。这些检测可用于基础研究和临床诊断。由于不同流感毒株之间抗原漂移或转移的频率很高,因此在流感诊断中特别需要广谱流感抗体。

义翘神州已鉴定出6对广谱抗体,分别针对甲型流感和乙型流感的NP蛋白。通过夹心法ELISA检测,这些抗原-抗体配对具有高灵敏度,可达到皮克级(pg)。

High Sensitivity (pg level)

Broad Spectrum and High Specificity

These antibody pairs can detect a broad spectrum of strains within the target subtype, without any cross-reactivity with the other subtypes.

24 kinds of influenza antigens from A or B have been tested by ELISA assay

Broad Spectrum and High Specificity

The Aforementioned Antigens:

B-1:  40783-V08B (B, B/Brisbane/60/2008) A-8:  40774-V08B (H1N1, A/Victoria/2570/2019 | A/Wisconsin/588/2019)
B-2:  40782-V08B (B, B/Colorado/06/2017) A-9:  40033-V08B (H2N2, A/Ann Arbor/6/1960)
B-3:  40438-V08B (B, B/Florida/4/2006) A-10:  40207-V08B (H3N2, A/Aichi/2/1968)
B-4:  40500-V08B (B, B/Phuket/3073/2013) A-11:  40778-V08B (H3N2, A/Cambodia/e0826360/2020 (H3N2)-like)
B-5:  40755-V08B (B, B/Washington/02/2019) A-12:  40208-V08B (H3N2, A/Hong Kong/1/1968)
A-1:  40204-V08B (H1N1, A/Brevig Mission/1/1918) A-13:  40753-V08B (H3N2, A/Hong Kong/2671/2019)
A-2:  40776-V08B (H1N1, A/Brisbane/02/2018) A-14:  40754-V08B (H3N2, A/Hong Kong/45/2019)
A-3:  40205-V08B (H1N1, A/California/07/2009) A-15:  40781-V08B (H3N2, A/Hong Kong/4801/2014 )
A-4:  40723-V08B (H1N1, A/Guangdong-Maonan/SWL1536/2019) A-16:  40779-V08B (H3N2, A/Kansas/14/2017)
A-5:  40724-V08B (H1N1, A/Hawaii/70/2019) A-17:  40499-V08B (H3N2, A/Switzerland/9715293/2013)
A-6:  40777-V08B (H1N1, A/Michigan/45/2015) A-18:  40110-V08B (H7N9, A/Anhui/1-BALF_RG6/2013)
A-7:  11675-V08B (H1N1, A/Puerto Rico/8/34/Mount Sinai) A-19:  40111-V08B (H7N9, A/Shanghai/2/2013)

High Binding Affinity

  • The binding affinity between immobilized Influenza B NP protein (Cat#: 40500-V08B) with the anti-NP antibody (Cat#: 40438-R036) in BLI assay.

  • The binding affinity between immobilized Influenza A NP protein (Cat#: 40774-V08B) with the anti-NP antibody (Cat#: 40205-R063) in BLI assay.

  • Antibody Cocktail Can Successfully Detect both A and B Type Flu

    The combination of A and B antibody pairs can allow detection of both subtypes.

  • High Production Quality
     

    Our products and processes are ISO13485 certified. The purity of these antibodies is >95% as assessed by SEC-HPLC.

Other Pan Influenza NP Antibodies

16 Pan Influenza A or B Nucleoprotein antibodies have been developed and validated by ELISA and WB assays.

Pan Influenza A NP Antibodies

40208-MM03   40208-R014   40208-MM04   40208-R010   40208-R061
 
40208-R113   40208-R117   40205-MM16   40205-MM18   40205-R063

Pan Influenza B NP Antibodies

40438-MM05  40438-R016  40438-MM09  40438-R036  40438-R004  40438-MM10

Western Blot Analysis of Nucleoprotein Antibodies to 24 Influenza Antigens

Lane 1: 40204-V08B | H1N1 (A/Brevig Mission/1/1918)
Lane 2: 40776-V08B | H1N1 (A/Brisbane/02/2018)*
Lane 3: 40205-V08B | H1N1 (A/California/07/2009)
Lane 4: 40723-V08B | H1N1 (A/Guangdong-Maonan/SWL1536/2019)*
Lane 5: 40724-V08B | H1N1 (A/Hawaii/70/2019)*
Lane 6: 40777-V08B | H1N1 (A/Michigan/45/2015)*
Lane 7: 11675-V08B | H1N1 (A/Puerto Rico/8/34/Mount Sinai)
Lane 8: 40774-V08B | H1N1 (A/Victoria/2570/2019A/Wisconsin/588/2019)
Lane 9: 40033-V08B | H2N2 (A/Ann Arbor/6/1960)
Lane 10: 40207-V08B | H3N2 (A/Aichi/2/1968)
Lane 11: 40778-V08B | H3N2 (A/Cambodia/e0826360/2020 (H3N2)-like)
Lane 12: 40208-V08B | H3N2 (A/Hong Kong/1/1968)
Lane 13: 40753-V08B | H3N2 (A/Hong Kong/2671/2019)*
Lane 14: 40754-V08B | H3N2 (A/Hong Kong/45/2019)*
Lane 15: 40781-V08B | H3N2 (A/Hong Kong/4801/2014)*
Lane 16: 40779-V08B | H3N2 (A/Kansas/14/2017)*
Lane 17: 40499-V08B | H3N2 (A/Switzerland/9715293/2013)*
Lane 18: 40110-V08B | H7N9 (A/Anhui/1-BALF_RG6/2013)
Lane 19: 40111-V08B | H7N9 (A/Shanghai/2/2013)
Lane 20: 40783-V08B | Influenza B (B/Brisbane/60/2008)*
Lane 21: 40782-V08B | Influenza B (B/Colorado/06/2017)*
Lane 22: 40438-V08B | Influenza B (B/Florida/4/2006)
Lane 23: 40500-V08B | Influenza B (B/Phuket/3073/2013)*
Lane 24: 40755-V08B | Influenza B (B/Washington/02/2019)*

*: Antigen from 2015-2022 Influenza Vaccine Strain

Pan Influenza A and B Hemagglutinin Antibody

Because of the distinct role of HA, it is widely used for research on antibodies against influenza. WB and ELISA assay have been performed to confirm the recognition of HA antigens. Results show that rabbit Mab 86001-RM01 and 11053-R004 are broad spectrum antibodies for Influenza A and B, respectively.

Western Blot Analysis of Hemagglutinin Antibodies to 20 Influenza Antigens


  • Anti-Influenza A HA rabbit mAb (Cat#: 86001-RM01) at 1:5000 dilution.

  • Anti-Influenza B HA rabbit mAb (Cat#: 11053-R004) at 1:10000 dilution.

Lane 1: 40719-V08H | H1N1 (A/Brisbane/02/2018) *
Lane 2: 11055-V08H | H1N1 (A/California/04/2009)
Lane 3: 11085-V08B | H1N1 (A/California/07/2009)*
Lane 4: 40717-V08H | H1N1 (A/Guangdong-Maonan/SWL1536/2019)*
Lane 5: 40567-V08H1 | H1N1 (A/Michigan/45/2015)*
Lane 6: 11684-V08H | H1N1 (A/Puerto Rico/8/1934)
Lane 7: 40787-V08H | H1N1 (A/Wisconsin/588/2019) / (A/Victoria/2570/2019) *
Lane 8: 11056-V08H | H3N2 (A/Brisbane/10/2007)
Lane 9: 40789-V08H | H3N2 (A/Cambodia/e0826360/2020)*
Lane 10: 40721-V08H | H3N2 (A/Hong Kong/2671/2019)*
Lane 11: 40765-V08H | H3N2 (A/Hong Kong/45/2019)*
Lane 12: 40555-V08B | H3N2 (A/Hong Kong/4801/2014)*
Lane 13: 40720-V08H | H3N2 (A/Kansas/14/2017) *
Lane 14: 40580-V08H | H3N2 (A/Singapore/INFIMH-16-0019/2016)*
Lane 15: 40497-V08B | H3N2 (A/Switzerland/9715293/2013)*
Lane 16: 40016-V08B | Influenza B (B/Brisbane/60/2008)*
Lane 17: 40581-V08H | Influenza B (B/Colorado/06/2017)*
Lane 18: 11053-V08H | Influenza B (B/Florida/4/2006)
Lane 19: 40498-V08B | Influenza B (B/PHUKET/3073/2013)*
Lane 20: 40722-V08H Influenza B (B/Washington/02/2019)*

了解更多产品信息,可通过以下方式联系我们:
北京义翘神州科技股份有限公司

电话:400-890-9989
邮箱:marketing@sinobiological.cn
官网:cn.sinobiological.com
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