IL-21: A Modulator in Allergy, Cancer, and Viral Infections
Interleukin 21 (IL-21) is an IL-2 family cytokine that strongly associated with inflammation and autoimmunity. It also exerts divergent effects on lymphoid cell leukemia and lymphomas. Clinical trials with IL-21 have yielded favorable results in cancer treatment, while the development of IL-21 inhibitors is in progress for treating autoimmune diseases. The biological functions of IL-21 are mediated via a heterodimeric receptor consisting of the IL-21R and the common γ-chain (γc/CD132) receptor. The latter is shared with other IL-2 family cytokines (IL‐4, IL‐7, IL‐9, IL‐15, and IL‐21).
Human IL-21 Protein: 10584-HNAE | ||||||
High-purity | Low-endotoxin | Tag-free | HPLC-verified |
Ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells. |
Batch-to-batch Consistency |
> 95% as determined by SEC-HPLC |
More Related Proteins
IL‐4 | IL‐7 | IL‐9 | IL‐15 | CD132 | IL-21R |