北京义翘神州

IL-21: A Modulator in Allergy, Cancer, and Viral Infections

Interleukin 21 (IL-21) is an IL-2 family cytokine that strongly associated with inflammation and autoimmunity. It also exerts divergent effects on lymphoid cell leukemia and lymphomas. Clinical trials with IL-21 have yielded favorable results in cancer treatment, while the development of IL-21 inhibitors is in progress for treating autoimmune diseases. The biological functions of IL-21 are mediated via a heterodimeric receptor consisting of the IL-21R and the common γ-chain (γc/CD132) receptor. The latter is shared with other IL-2 family cytokines (IL‐4, IL‐7, IL‐9, IL‐15, and IL‐21).

Human IL-21 Protein: 10584-HNAE
 
High-purity   Low-endotoxin   Tag-free   HPLC-verified

Ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells.
 
Batch-to-batch Consistency
 
> 95% as determined by SEC-HPLC
More about Recombinant IL-21 >>>

More Related Proteins

IL‐4   IL‐7   IL‐9   IL‐15   CD132   IL-21R

IL-1β Primes Innate Immunity

Interleukin-1β (IL-1β), along with IL1-alpha and IL18, orchestrate the immune response through multiple downstream mechanisms. IL1-beta transduces its signal through binding with the receptor IL1RI, which is complexed with the accessory protein IL1RACP. IL1-beta signaling is negatively regulated by the decoy receptor IL1-RII, and the receptor antagonist IL1RA.

Human IL-1β Protein: 10139-HNAE
 
High-purity   Low-endotoxin   Tag-free   HPLC-verified

Ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells.
 
Batch-to-batch Consistency
 
> 95% as determined by SEC-HPLC
More about Recombinant IL-1 beta >>>

More Related Proteins

IL-1R1   IL-1RACP   IL-1R2   IL-1α   IL-18

TNF-α: Inflammatory Cytokine with Tumor Necrosis Activity

Tumour Necrosis Factor α (TNF-α) is an inflammatory cytokine responsible for necrosis or apoptosis, playing therapeutic roles in immunostimulation, infection resistance, embryonic development, and resistance to tumours. TNF-α exerts function by binding to TNFR-1 or TNFR-2 which belong to TNF receptor superfamily. FAS, CD40, CD27, and RANK are also members of TNF receptor superfamily

Human TNF-α Protein: 10602-HNAE
 
High-purity   Low-endotoxin   Tag-free   HPLC-verified

Cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D.
 
Batch-to-batch Consistency
 
> 95% as determined by SEC-HPLC
More about Recombinant TNF-α >>>

More Related Proteins

TNFR-1   TNFR-2   FAS   CD40   CD27   RANK
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