1952 电泳技术
1967 发现DNA连接酶
1969 FISH
1970 发现限制性酶
发现逆转录
1972 克隆技术
1975 Southern blot
1977 DNA sequencing
1980 RFLP concept
1982 P-element-mediated manipulation of
the fly genome
全基因组鸟枪法
1983 RFLP realization
1985 PCR
DNA fingerprinting
1987 YACs
Site-directed
mutagenesis of the
mouse genome |
1988 ChIP
1990 BLAST — 比较基因组学关键
技术
1992 BACs
1995 Microarray technology
1998 RNAi
合成测序法(Sequencing by synthesis )
全长cDNA技术
2002 Launch of UCSC Genome
Browser
2003 DNA拼装程序
(DNA assembly programs)
2004 ENSEMBL — 基因注解工具
范例
2005 HapMap
ligation/polony测序
2006 DNA甲基化全基因组图谱 |