首页 > 核心刊物 > 遗传 2018.1 Vol 40, No.1 > GATA6在肝脏发育中的作用及调控机制

GATA6在肝脏发育中的作用及调控机制

张玲, 何建波

西南大学生命科学学院,淡水鱼类资源与生殖发育教育部重点实验室,重庆 400715

 
Key Words:  GATA6, 肝脏发育, 转录因子, 先锋因子, 重编程
 

Abstract

GATA6 (GATA binding protein 6)是GATA锌指转录因子家族成员之一,以其保守的结合基序(G/A)GATA(A/T) 而得名。GATA家族在脊椎动物细胞命运决定与分化、增殖和迁移以及内胚层和中胚层来源的器官发育中具有重要作用。GATA6作为谱系特化因子、染色质重塑因子、多能性因子和“先锋因子”,在内胚层肝脏谱系决定、肝脏特化、肝芽生长以及肝母细胞增殖分化等阶段发挥关键的调控作用。本文综述了GATA6在肝脏发育中的作用及其研究进展,以期为进一步研究 GATA6 等发育关键转录因子的功能及调控机制提供参考。


 

Abstract

GATA binding protein 6 (GATA6) is a member of the GATA family of zinc-finger transcriptional regulators, whose names come from the conservative base sequence (G/A)GATA(A/T). The GATA families play key roles in cell fate determination, proliferation, migration, and organogenesis of endoderm- and mesoderm-derived organs in vertebrates. As a lineage-specific factor, a chromatin remodeling factor, a pluripotent factor and a pioneer factor, GATA6 is involved in various stages of liver development, including endoderm liver-lineage determination, liver specification, hepatic bud outgrowth and hepatoblast differentiation. In this review, we summarize recent progress in the roles and regulatory mechanisms of GATA6 in liver development.


期刊简介
 
主办单位:

编辑单位:《遗传》 编辑部
主 编: 张永清
主 任: 张颖
编委阵容 :审稿专家
国内刊号:CN11-1913/R
国际刊号:ISSN 0253-9772
邮发代号: 2-810