联系方式

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020-87511980-213

• E-mail
hrgz@ebiotrade.com

登陆编号:

10910

性别:

国籍:

留学国家:

美国

国外所获学位:

博士后

专注领域:

表观遗传学,免疫学

求职意向:

高校,科研院所,企业

期望薪金:

工作地区或城市:

北京

发表的学术论文:

1. Zhang, H.*, Gan, H.*, Wang, Z.*, Lee, JH., Zhou, H., Ordog, T., Wold, M., Ljungman, M., Zhang, Z. (2017) RPA interacts with HIRA and regulates H3.3 deposition at gene regulatory elements in mammalian cells. Molecular Cell 65(2) : 272-284 (IF: 13.958 )

2. Wang, Z. *, Zhang, H. *, Liu, J., Cheruiyot, A., Lee JH., Ordog, T., Lou, Z., You Z., Zhang, Z. (2016) USP51 deubiquitylates H2AK13, 15ub and regulates DNA damage response. Genes Dev. 30(8) : 946-59(Co-first author) (IF: 10.042)

3. Fang, D., Gan, H., Lee, JH., Han, J., Wang, Z., Riester SM., Jin, L., Chen, J., Zhou, H., Wang, J., Zhang, H., Yang, N., Bradley, EW., Ho, TH., Rubin, BP., Bridge, JA. Thibodeau, SN., Ordog, T., Chen, Y., van Wijnen, AJ., Oliveira, AM., Xu, RM., Westendorf, JJ., Zhang, Z. (2016) The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 352(6291) : 1344-8 (IF: 34.661)

4. Han, J., Zhang, H., Zhang, H., Wang, Z., Zhou, H., Zhang, Z. (2013) A Cul4 E3 ubiquitin ligase regulates Histone hand-off during nucleosome assembly. Cell. 155(4):817–829 (IF: 28.71)

5. Wu, R., Wang, Z., Zhang, H., Gan, H., Zhang, Z. (2016) H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication. Nucleic Acids Res. 45(1) : 169-180 (IF: 9.202)

6. Liu, S*., Zhang, H. *, Li, M., Hu, D., Li, C., Ge, B., Jin, B., Fan, Z.(2013)
Recruitment of the adaptor Grb2 and SHIP1 by the ITT-like motif of TIGIT
suppresses granule polarization and cytotoxicity of NK cells. Cell Death Differ. 20(3):456-64. (Co-first author) (IF: 8.218)

7. Zhang, H., Zhong, C., Shi, L., Guo, Y ., Fan, Z. (2009). Granulysin induces cathepsin B release from lysosomes of target tumor cells to attack mitochondria through processing of Bid leading to necroptosis. J. Immunol. 182,6993-7000. (IF: 4.985 )

8. Zhao, T*., Zhang, H. *, Guo, Y., Fan, Z. (2007). Granzyme K directly processes Bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. J. Biol. Chem. 282,12104–12111. (Co-first author) (IF: 4.258)

9. Chen J, Hao L, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li P, Tian Y, Fan Z. (2015). The endoplasmic reticulum adaptor protein ERAdP initiates NK cell activation via the Ubc13-mediated NF-κB pathway. J. Immunol. 194,1292-303.

10. Li, M., Xia, P., Du, Y., Liu, S., Huang, G., Chen, J., Zhang, H., Hou, N., Cheng, X., Li, P.,Yang, X., Fan,Z.(2014). T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling. J. Biol. Chem. 289:17647-57.

11. Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z. (2013). Identification of SERPINB1 as a physiological inhibitor of human granzyme H. J. Immunol. 190, 1319-30.

12. Tang, H., Li, C., Wang, L., Zhang, H., Fan, Z. (2012). Granzyme H of cytotoxic lymphocytes is required for clearance of the hepatitis B virus through cleavage of the hepatitis B virus X protein . J. Immunol. 188, 824-31.

13. Wang, L., Zhang, K., Wu, L., Liu, S., Zhang, H., Zhou, Q., Tong, L., Sun, F., Fan, Z. (2012). Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif. J. Immunol. 188, 765-73.

14. Hou, Q., Zhao, T., Zhang, H., Lu, H., Zhang, Q., Sun L., Fan, Z. (2008). Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. Mol. Immunol. 45, 1044–1055.

15. Zhao, T., Zhang, H., Guo, Y., Zhang, Q., Hua, G., Lu, H., Hou, Q., Liu, H., and Fan, Z. (2007). Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. Cell Death Differ. 14, 489-499.

16. Fan, Z., Zhang, H., Zhang, Q. (2006). Tumor suppressor pp32 represses cell growth through inhibition of transcription by blocking acetylation and phosphorylation of histone H3 and initiating its proapoptotic activity. Cell Death Differ. 13, 1485-1494.

17. Lu, H., Hou, Q., Zhao, T., Zhang, H., Zhang, Q., Wu, L., Fan, Z. (2006). Granzyme M directly cleaves inhibitor of caspase-activated DNase to unleash CAD leading to DNA fragmentation. J. Immunol. 177, 1171-1178.

18. Zhang, H., Yao, B., Wang, Y. (2003). Characterization, gene cloning and expression of new xylanase XYNB with high specific activity. Chinese Science Bulletin. 48(8), 761-765. (IF: 1.789)

19. Zhang, H., Yao, B., Wang, Y., Yuan T., Zhang W., Wu N., Fan Y. (2003). Expression of Xylanase Gene xynA from Streptomyces olivaceoviridis A1 in Escherichia coli and Pichia pastoris. Chinese Journal of Biotechnology, 19(1), 41-45

20. Zhang, H., Yao, B., Yuan, T., Wang, Y., Cao, S., Fan, Y. (2002). Purification and Properties of 43 kD Xylanase XYNA from Streptomyces olivaceoviridis A1. Journal of Agricultural Biotechnology. 10(1), 10-14.

21. Zhang, H., Yao, B., Fan, Y. (2002). Molecular Biology and Applications of Xylanase. Biotechnology Bulletin. 3, 23-26.

主要成就:

1.组蛋白变体H3.3核小体组装的新调控因子筛选及作用机制研究
2.NK 细胞特化蛋白颗粒溶素,颗粒酶K,颗粒酶H诱导肿瘤细胞凋亡机理研究及TIGIT受体信号通路调节NK细胞活性机制的研究


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