生物通报道:糖生物学(Glycobiology)是糖的化学和生物学研究相结合而产生的一门新兴学科,近20年来糖生物学研究取得了很多重要成就。本周《Nature》
的专题内容就是Glycochemistry & Glycobiology。
碳水化合物(carbohydrates)在生物过程中的重要性长久以来并未获得充分的认识。现在利用合成,修饰,寡聚糖(oligosaccharides)和复合糖(glycoconjugates)研究,我们对于这些生物分子正在加速深入了解,这些认知有助于我们筛选以碳水化合物为基础的诊断,药物和治疗方法。目前许多国家对糖生物学研究都给予了足够的支持和重视,糖生物学已成为生命科学研究的前沿和新热点.
《Nature》这一专题包括了一篇社论和七篇综述,均为免费下载:
Editorial
Glycochemistry & Glycobiology
Joshua Finkelstein
doi:10.1038/446999a
Full Text | PDF (104KB)
Reviews
Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines
Danica P. Galoni & David Y. Gin
doi:10.1038/nature05813
Abstract | Full Text | PDF (460KB)
Unusual sugar biosynthesis and natural product glycodiversification
Christopher J. Thibodeaux, Charles E. Melançon & Hung-wen Liu
doi:10.1038/nature05814
Abstract | Full Text | PDF (704KB)
Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins
Gerald W. Hart, Michael P. Housley & Chad Slawson
doi:10.1038/nature05815
Abstract | Full Text | PDF (566KB)
Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins
Ajit Varki
doi:10.1038/nature05816
Abstract | Full Text | PDF (781KB)
Heparan sulphate proteoglycans fine-tune mammalian physiology
Joseph R. Bishop, Manuela Schuksz & Jeffrey D. Esko
doi:10.1038/nature05817
Abstract | Full Text | PDF (3,116KB)
Exploiting the defensive sugars of HIV-1 for drug and vaccine design
Christopher N. Scanlan, John Offer, Nicole Zitzmann & Raymond A. Dwek
doi:10.1038/nature05818
Abstract | Full Text | PDF (1,800KB)
Synthesis and medical applications of oligosaccharides
Peter H. Seeberger & Daniel B. Werz
doi:10.1038/nature05819
Abstract | Full Text | PDF (277KB)
(生物通:张迪)
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