同时在1月《G&D》上的，来自纽约约斯隆/凯德琳癌症研究中心（Memorial Sloan-Kettering Cancer Center）发育生物学系的赖教授（Eric C.Lai）也有相似的发现，而来自哈佛医学院的Welcome Bender博士则证明了miR-iab-4的敲除揭示了一种从相反链转录的miRNA的存在，而且反义miRNA的缺失会引起一个hox基因的些轻微去抑制（derepression）。这些在果蝇和哺乳动物中发现的额外的反义miRNA说明这种新机制也许能增加科学家们对miRNA功能的多样化的了解。
（生物通：张迪）

原文检索：
GENES & DEVELOPMENT 22:8-13, 2008
A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands
[Abstract]

附：
Manolis Kellis, Ph.D.
Assistant Professor of Computer Science

MIT Computer Science and Artificial Intelligence Laboratory
Broad Institute of MIT and Harvard
Stata Center - 32G.826 - 617.253.2419

Karl Van Tassel Career Development Chair, 2007
National Science Foundation Career Award, 2007
Technology Review Top Young Innovators, 2006
Distinguished Alumnus (1964) Career Development Chair, 2005

Research Interests

Computational Biology
HumanMotifs - Motif discovery in the human genome
Duplication - Genome duplication in yeast
Yeast - Gene identification and motif discovery in yeast
6.895 - Computational Biology: Genomes, Networks, Evolution
Hox - Developmental gene clusters in mammals
Evolution - Computational requirements for evolvability
Thesis - Received Sprowls award for best PhD thesis in CS 
 

上一页 [1] [2] 下一页