Cancer Res:黑莓改变数百癌症基因表达

【字体: 时间:2008年09月01日 来源:生物通

编辑推荐:

   一项新的研究证实,使用浓缩的黑木莓(black raspberries,又称黑覆盆子)提取物结合其他预防药物可有效改变癌症相关的数百个基因,这比单独使用预防药物改变单个基因更为有效。

  



原文摘要:Carcinogen-Altered Genes in Rat Esophagus Positively Modulated to Normal Levels of Expression by Both Black Raspberries and Phenylethyl Isothiocyanate

Cancer Research 68, 6460-6467, August 1, 2008. doi: 10.1158/0008-5472.CAN-08-0146

 

【Abstract】

Our recent study identified 2,261 dysregulated genes in the esophagi of rats that received a 1-week exposure to the carcinogen N-nitrosomethylbenzylamine (NMBA). We further reported that 1,323 of these genes were positively modulated to near-normal levels of expression in NMBA-treated animals that consumed dietary phenylethyl isothiocyanate (PEITC), a constituent of cruciferous vegetables. Herein, we report our results with companion animals that were fed a diet containing 5% freeze-dried black raspberries (BRB) instead of PEITC. We found that 462 of the 2,261 NMBA-dysregulated genes in rat esophagus were restored to near-normal levels of expression by BRB. Further, we have identified 53 NMBA-dysregulated genes that are positively modulated by both PEITC and BRB. These 53 common genes include genes involved in phase I and II metabolism, oxidative damage, and oncogenes and tumor suppressor genes that regulate apoptosis, cell cycling, and angiogenesis. Because both PEITC and BRB maintain near-normal levels of expression of these 53 genes, their dysregulation during the early phase of NMBA-induced esophageal cancer may be especially important in the genesis of the disease. [Cancer Res 2008;68(15):6460–7]

 

(生物通 张欢)

 

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