-
生物通官微
陪你抓住生命科技
跳动的脉搏
生物通官微
陪你抓住生命科技
跳动的脉搏
《Nature》专题：解读“iPS”三大趋势
【字体： 大 中 小 】 时间：2009年07月07日 来源：生物通
编辑推荐：
生物通报道，近期的iPS研究十分热门，为此Nature也专门推出了一个iPS专题（Web Focus on iPS Cells），围绕着iPS从三个方面解读它的发展趋势。
生物通报道，近期的iPS研究十分热门，为此Nature也专门推出了一个iPS专题（Web Focus on iPS Cells），围绕着iPS从三个方面解读它的发展趋势。
如果说21世纪是干细胞的世纪，那么干细胞领域中最璀璨的明星莫过于“iPS”技术。往体细胞中导入KLF4、OCT4、SOX2和C-MYC四种基因，即可将正常体细胞转化成多能干细胞（iPS细胞）。
iPS出现短短2年，已经向多元化方向发展。本期的Nature从多能性（proving pluripotency）、安全性（safer iPS）以及疾病型iPS细胞（Making Human disease cells）三个方面解析iPS最近进展。
Proving pluripotency
Article
Reprogramming of human somatic cells to pluripotency with defined factors
In-Hyun Park et al.
Nature 451, 141–146 (10 January 2008) doi:10.1038/nature06534
Abstract | Full Text | PDF | Supplementary Information
Article
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
Marius Wernig et al.
Nature 448, 318–324 (19 July 2007) doi:10.1038/nature05944
Abstract | Full Text | PDF | Supplementary Information
Article
Generation of germline-competent induced pluripotent stem cells
Keisuke Okita, Tomoko Ichisaka & Shinya Yamanaka
Nature 448, 313–317 (19 July 2007) doi:10.1038/nature05934
Abstract | Full Text | PDF | Supplementary Information
Safer iPS
Letter
Virus-free induction of pluripotency and subsequent excision of reprogramming factors
Keisuke Kaji et al.
Nature 458, 771–775 (9 April 2009) doi:10.1038/nature07864
Abstract | Full Text | PDF | Supplementary Information
Letter
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
Knut Woltjen et al.
Nature 458, 766–770 (9 April 2009) doi:10.1038/nature07863
Abstract | Full Text | PDF | Supplementary Information
News and Views
Stem cells: Low-risk reprogramming
Martin F. Pera
Nature 458, 715–716 (9 April 2009) doi:10.1038/
Letter
Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors
Jeong Beom Kim et al.
Nature 454, 646–650 (31 July 2008) doi:10.1038/nature07061
Abstract | Full Text | PDF | Supplementary Information
Making human disease cells
Article
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
Ángel Raya et al.
Nature advance online publication 31 May (2009) doi:10.1038/nature08129
Abstract | Full Text | PDF | Supplementary Information
Article
Induced pluripotent stem cells from a spinal muscular atrophy patient
Allison D. Ebert et al.
Nature 457, 277–280 (15 January 2009) doi:10.1038/nature07677
Abstract | Full Text | PDF | Supplementary Information
News
Reprogrammed skin cells provide testing ground for new drugs
Asher Mullard
Nature News 22 December (2008) doi:10.1038/news.2008.1323
News and Views
Motor neuron disease: The curious ways of ALS
Magdalini Polymenidou & Don W. Cleveland
Nature 454, 284–285 (17 July 2008) doi:10.1038/
生物通 小茜
