李辉教授受邀在Cell子刊Trends in cancer发表融合基因评论

【字体: 时间:2016年08月30日 来源:生物通

编辑推荐:

  基因融合一直被认为是肿瘤独有的特征,近期来自美国佛吉尼亚大学李辉实验室的研究人员发现几乎所有正常器官和组织中都存在融合基因,且具有极其重要的生理功能。

  

基因融合一直被认为是肿瘤独有的特征,近期来自美国佛吉尼亚大学李辉实验室的研究人员发现几乎所有正常器官和组织中都存在融合基因,且具有极其重要的生理功能。李辉教授的研究方向是融合基因在肿瘤和正常发育过程中的病理和生理功能以及分子机制。这篇评论总结了融合基因领域的进展和未来发展方向. 目标是寻找肿瘤早期诊断和临床预后的标志性融合基因。

文章第一作者是博士生贾月萌和博士后谢仲秋。评论中总结了李辉实验室取得的两项进展:一是RNA反式剪辑“RNA trans-splicing”,两个单独的RNA可以拼接在一起并产生一融合RNA,翻译成融合蛋白在正常生理发育过程中行使功能。成果发表在顶尖刊物Science( Li H, et al: A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. Science2008, 321:1357-1361. http://www.ncbi.nlm.nih.gov/pubmed/18772439.)和
Cancer Discovery(Yuan H,et al: Chimeric RNA characteristic of rhabdomyosarcoma in normal myogenesis process. Cancer Discov 2013, 3:1394-1403.http://www.ncbi.nlm.nih.gov/pubmed/24089019. )
;二是在肿瘤里两个相邻的基因在相同的方向转录,相邻基因的顺式剪接“Splicing of Adjacent Genes (cis-SAGe)” 发表在Cancer Discovery (Zhang Y, et al: Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation. Cancer Discov 2012, 2:598-607.http://www.ncbi.nlm.nih.gov/pubmed/22719019. 和Plos Genetics (Qin F,et al : Discovery of CTCF-sensitive Cis-spliced fusion RNAs between adjacent genes in human prostate cells. PLoS Genet 2015, 11:e1005001.http://www.ncbi.nlm.nih.gov/pubmed/25658338. )

李辉教授本科毕业于中国科技大学物理化学专业,在美国取得生物学博士学位,目前从事肿瘤领域和RNA领域研究,获得过
V Scholarship, Up To Cancer Innovator Award,St. Baldrick’s Scholar,The Ivy Foundation Biomedical Innovation Award,American Cancer Society Research Scholar 等多项荣誉。课题受NIH Ro1和美国癌症协会资助。

李辉博士简历:
2015 -present, Associate Professor, Department of Pathology, University of Virginia.
2009-2015, Assistant Professor, Department of Pathology, University of Virginia.
2006-2009, Associate Research Scientist, Pathology, Yale University, New Haven, CT
2003-2006, Postdoctoral Associate, Pathology, Yale University, New Haven, CT
1998-2003, Ph.D. Case Western Reserve University, Howard Hughes Medical Institute.
1993-1998,  B.Sc. University of Science and Technology of China. Major: Chemical Physics 

李辉实验室网页:http://lilab.medicine.virginia.edu/ 

李辉博士欢迎优秀学者访问交流!

原文摘要:

Intergenically Spliced Chimeric RNAs in Cancer

Gene fusions and their encoded products (fusion RNAs and proteins) are viewed as one of the hallmarks of cancer. Traditionally, they were thought to be generated solely by chromosomal rearrangements. However, recent discoveries of trans-splicing and cis-splicing events between neighboring genes suggest that there are other mechanisms to generate chimeric fusion RNAs without corresponding changes in DNA. In addition, chimeric RNAs have been detected in normal physiology, complicating the use of fusions in cancer detection and therapy. By contrast, ‘intergenically spliced’ fusion RNAs represent a new repertoire of biomarkers and therapeutic targets. We review here current knowledge on chimeric RNAs and implications for cancer detection and treatment, and discuss outstanding questions for the advancement of the field.


 

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