北京义翘神州
重组Spike突变体N501Y

最近几个月,全球范围内分离出了多种新的新冠突变毒株。其中, Alpha, Gamma, Beta, Delta以及最新分离出的Omicron具有很高的传染率,也因此备受关注。

在目前已经检测分离到的新冠突变株中,发生在Spike蛋白受体结合域的多个突变是主要的突变类型,也是最令人担心的突变。Spike蛋白受体结合域是新冠病毒结合宿主受体的主要结构,该结构的突变则有可能导致增强与受体的亲和力、减弱中和抗体效应或者造成病毒的免疫逃逸。

新冠突变株中同时存在N蛋白突变。N蛋白具有高度保守型,常被用作新冠抗原快速检测的标志物。目前已经上市的新冠抗原检测试剂是否可以检测到突变后的N蛋白以及检测灵敏度和特异性是否会受到突变的影响需要进一步的研究。

经过全球科学家的共同监测与研究,WHO公布了新冠VOC毒株以加快全球对于当下COVID-19大流行趋势的应对速度。VOC毒株具有以下几个特征:
• 传染性增强
• 病毒毒力增强或引起临床表征的变化
• 导致现行的诊断、疫苗以及治疗方法的有效性降低

WHO-Currently designated Variants of Concern

WHO label lineages Earliest documented samples
Alpha B.1.1.7 United Kingdom, Sep-2020
Beta B.1.351 South Africa, May-2020
Gamma P.1 Brazil, Nov-2020
Delta B.1.617.2 India, Oct-2020
Omicron B.1.1.529 Multiple countries, Nov-2021
 

WHO-Currently designated Variants of Interest

WHO label lineages Earliest documented samples
Lambda C.37 Peru, Dec-2020
Mu B.1.621 Colombia, Jan-2021

HOT: Omicron (B.1.1.529) Variants will be available soon. Contact us to pre-order.

义翘神州开发了200多种新冠突变体蛋白,可用于抗体、疫苗等效力研究。

新冠突变体蛋白试剂库

Omicron (B.1.1.529)

• Mutations in Omicron Spike

WHO 命名 货号 抗原 标签 表达宿主 突变位点
Omicron (B.1.1.529) 40588-V07E34 N N-His E.coli P13L, E31del, R32del, S33del, R203K, G204R
Omicron (B.1.1.529) 40592-V08H121 RBD C-His HEK293 G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H
Omicron (B.1.1.529) 40592-V49H7-B
Biotinylated
RBD C-His-AVI HEK293 G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H
Omicron (B.1.1.529) 40589-V08H26 S-ECD Trimer C-His HEK293 A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
Omicron (B.1.1.529) 40591-V08H41 S1 C-His HEK293 A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H
Omicron (B.1.1.529) 40589-V08B33
(pre-order)
S-ECD C-His Insect A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
Omicron (B.1.1.529) 40589-V49H3-B
Biotinylated
(pre-order)
S-ECD Trimer C-His-AVI HEK293 A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
Omicron (B.1.1.529) 40591-V08H42
(pre-order)
S-NTD C-His HEK293 A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I
Omicron (B.1.1.529) 40592-V05H3
(pre-order)
RBD C-mFc HEK293 G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H
Omicron (B.1.1.529) 40592-V02H8
(pre-order)
RBD C-Fc HEK293 G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H

Mu (B.1.621)

• Variants in S Protein

WHO 命名 毒株 货号 抗原 突变位点
Mu B.1.621 40588-V07E9 N T205I
Mu B.1.621 40589-V08H20 (pre-order) S1+S2 ECD T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H with prefusion trimer mutations construction
Mu B.1.621 40591-V08H38 S1 T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H
Mu B.1.621 40592-V08H118 RBD R346K, E484K, N501Y
Mu B.1.621 40592-V02H6 RBD R346K, E484K, N501Y

Lambda (C.37)

WHO 命名 毒株 货号 抗原 突变位点
Lambda C.37 40588-V07E31 N P13L, R203K, G204R, G214C
Lambda C.37 40592-V08H113 RBD L452Q, F490S
Lambda C.37 40589-V08B23 S1+S2 ECD G75V, T76I, R246N, Δ247, Δ253, L452Q, F490S, D614G, T859N
Lambda C.37 40589-V08B24 S1+S2 ECD G75V, T76I, R246del, S247del, Y248del, L249del, T250del, P251del, G252del, D253N, L452Q, F490S, D614G, T859N
Lambda C.37 40591-V08H31 S1 G75V, T76I, R246N, Δ247, Δ253, L452Q, F490S, D614G
Lambda C.37 40591-V08H32 S1 G75V, T76I, (RSYLTPG246-252)deletion, D253N, L452Q, F490S, D614G
Lambda C.37 40592-V49H6-B RBD L452Q, F490S

Delta/Delta plus (AY.1, AY.2, AY.3)

WHO 命名 毒株 货号 抗原 突变位点
Delta/Delta plus AY.1/AY.3 40588-V07E32 N D63G, R203M, G215C, D377Y
Delta/Delta plus AY.1/AY.2 40592-V08H115 RBD K417N, L452R, T478K
Delta/Delta plus AY.1/AY.2 40592-V49H5-B RBD K417N, L452R, T478K
Delta/Delta plus AY.1 40589-V08B25 S1+S2 ECD T19R, G142D, W258L, K417N, L452R, T478KD614G, D950N, P681R
Delta/Delta plus AY.2 40589-V08B26 S1+S2 ECD T19R, V70F, E156G, del157/158, A222V, K417N, L452R, T478K, D614G, P681R, D950N
Delta/Delta plus AY.3 40589-V08B27 S1+S2 ECD T19R, E156G, del157/158, L452R, T478K, D614G, P681R, D950N

Delta (B.1.617.2)

• Variants in S Protein

• Variants in N Protein

• Recombinant Delta (B.1.617.2) Variants

WHO 命名 货号 抗原 标签 表达宿主 突变位点
Delta (B.1.617.2) 40588-V07E29 N N-His E.coli D63G, R203M, D377Y
Delta (B.1.617.2) 40589-V49B4-B S1+S2 ECD C- His & AVI Insect cell 157-158deletion, T19R, G142D, E156G, L452R, T478K, D614G, P681R, D950N
Delta (B.1.617.2) 40589-V08B16 S1+S2 ECD C-His Insect cell T19R, G142D, E156G, del157/158, L452R, T478K, D614G, P681R, D950N
Delta (B.1.617.2) 40591-V08H23 S1 C-His HEK293 T19R, G142D, E156G, del157/158, L452R, T478K, D614G, P681R
Delta (B.1.617.2) 40591-V49H2-B S1 C- His & AVI HEK293 (157-158)deletion, T19R, G142D, E156G, L452R, T478K, D614G, P681R
Delta (B.1.617.2) 40592-V02H3 RBD C-hFc HEK293 L452R, T478K
Delta (B.1.617.2) 40592-V08H90 RBD C-His HEK293 L452R, T478K
Delta (B.1.617.2) 40592-V08H91 RBD C-His HEK293 T478K
Delta (B.1.617.2) 40592-V49H1-B RBD C- His & AVI HEK293 L452R, T478K

Alpha/Beta (B.1.1.7/ B.1.351/ A.2.2)

WHO 命名 毒株 货号 抗原 突变位点
Alpha/Beta B.1.1.7/ B.1.351/ A.2.2 40588-V07E2 N P13L

Alpha (B.1.1.7)

• Variants in S Protein

• Variants in N Protein

• Recombinant Alpha (B.1.1.7) Variants

WHO 命名 毒株 货号 抗原 突变位点
Alpha B.1.1.7 40588-V07E1 N R203K, G204R
Alpha B.1.1.7 40588-V07E17 N E378Q
Alpha B.1.1.7 40588-V07E4 N I292T
Alpha B.1.1.7 40588-V07E7 N D3L, R203K, G204R, S235F
Alpha B.1.1.7 40588-V07E8 N D3L, S235F
Alpha B.1.1.7/ B.1.237 40588-V07E3 N S194L
Alpha B.1.1.7 40589-V08B6 S1+S2 ECD H69del, V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H
Alpha B.1.1.7 40589-V49B-B S1+S2 ECD H69del, V70del, Y145del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H
Alpha B.1.1.7 40591-V08H12 S1 H69del, V70del, Y144del, N501Y, A570D, D614G, P681H
Alpha B.1.1.7 40591-V08H12-B S1-Biotinylated H69del, V70del, Y144del, N501Y, A570D, D614G, P681H
Alpha B.1.1.7 40591-V08H7 S1 HV69-70deletion, N501Y, D614G
Alpha B.1.1.7 40591-V49H4-B S1 (HV69-70, Y145)deletion, N501Y, A570D, D614G, P681H
Alpha B.1.1.7 40592-V02H1 RBD N501Y
Alpha B.1.1.7 40592-V08H18 RBD S494P
Alpha B.1.1.7 40592-V08H82 RBD N501Y
Alpha B.1.1.7 40592-V08H82-B RBD N501Y
Alpha B.1.1.7 40592-V49H2-B RBD N501Y

Alpha/Beta/Gamma (B.1.1.7/ B.1.351/ P.1)

WHO 命名 毒株 货号 抗原 突变位点
Alpha/Beta/Gamma B.1.1.7/ B.1.351/ P.1 40592-V31H1 RBD N501Y

Beta (B.1.351)

• Variants in S Protein

• Variants in N Protein

• Recombinant Beta (B.1.351) Variants

WHO 命名 毒株 货号 抗原 突变位点
Beta B.1.351/B.1.351.2/
B.1.351.3/B.1.427/B.1.429
40588-V07E9 N T205I
Beta B.1.351 40589-V08B11 S1+S2 ECD D80A, L242del, A243del, L244del, R246I, E484K, K417N, N501Y, D614G, A701V
Beta B.1.351/B.1.351.2/B.1.351.3 40589-V08B7 S1+S2 ECD L18F, D80A, D215G, LAL242-244deletion, R246I, K417N, E484K, N501Y, D614G, A701V
Beta B.1.351/B.1.351.2/B.1.351.3 40589-V08B9 S1+S2 ECD D80A, K417N, E484K, N501Y, D614G, A701V
Beta B.1.351 40589-V49B1-B S1+S2 ECD
Beta B.1.351 40589-V08B7-B S1+S2-Biotinylated L18F, D80A, D215G, LAL242-244deletion, R246I, K417N, E484K, N501Y, D614G, A701V
Beta B.1.351/B.1.351.2/B.1.351.3 40591-V08H13 S1 NTD L18F, D80A, D215G, LAL242-244deletion, R246I
Beta B.1.351 40591-V08H10-B S1 K417N, E484K, N501Y, D614G
Beta B.1.351/B.1.351.2/B.1.351.3 40591-V08H10 S1 K417N, E484K, N501Y, D614G
Beta B.1.351/B.1.351.2/B.1.351.3 40591-V08H15 S1 L18F, D80A, D215G, LAL242-244deletion, R246I, K417N, E484K, N501Y, D614G
Beta B.1.351/B.1.351.2/B.1.351.3 40591-V49H5-B S1 (LAL242-244)deletion, L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G
Beta B.1.351 40592-V08H59 RBD K417N
Beta B.1.351 40592-V08H59-B RBD K417N
Beta B.1.351 40592-V08H84 RBD E484K
Beta B.1.351 40592-V08H84-B RBD E484K
Beta B.1.351 40592-V08H85-B RBD K417N, E484K, N501Y
Beta B.1.351 40592-V31H2 RBD E484K
Beta B.1.351 40592-V31H6 RBD K417N
Beta B.1.351/ B.1.351.3 40592-V31H4 RBD K417N, E484K, N501Y
Beta B.1.351/B.1.351.2/B.1.351.3 40592-V02H4 RBD K417N, E484K, N501Y
Beta B.1.351/B.1.351.2/B.1.351.3 40592-V08H85 RBD K417N, E484K, N501Y
Beta B.1.351/B.1.351.2/B.1.351.3 40592-V49H3-B RBD K417N, E484K, N501Y

Gamma (P.1/ P.1.1/ P.1.2)

• Variants in S Protein

• Variants in N Protein

• Recombinant Gamma (P.1/ P.1.1/ P.1.2) Variants

WHO 命名 毒株 货号 抗原 突变位点
Gamma P.1/ P.1.1/ P.1.2 40588-V07E11 N P80R
Gamma P.1/ P.1.1/ P.1.2 40589-V08B10 S1+S2 ECD L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F
Gamma P.1/ P.1.1/ P.1.2 40589-V08B8 S1+S2 ECD L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I
Gamma P.1/ P.1.1/ P.1.2 40591-V08H14 S1 L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y
Gamma P.1/ P.1.1/ P.1.2 40591-V08H5 S1 T20N, D614G
Gamma P.1/ P.1.1/ P.1.2 40591-V49H6-B S1 L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y
Gamma P.1/ P.1.1/ P.1.2 40592-V02H5 RBD K417T, E484K, N501Y
Gamma P.1/ P.1.1/ P.1.2 40592-V08H86 RBD K417T, E484K, N501Y
Gamma P.1/ P.1.1/ P.1.2 40592-V31H5 RBD K417T, E484K, N501Y
Gamma P.1/ P.1.1/ P.1.2 40592-V31H7 RBD K417T
Gamma P.1/ P.1.1/ P.1.2 40592-V49H4-B RBD E484K, K417T, N501Y

Epsilon (B.1.427/429)

WHO 命名 毒株 货号 抗原 突变位点
Epsilon B.1.427 40591-V08H27 S1 L452R, D614G
Epsilon B.1.429/B.1.427 40591-V08H17 S1 W152C, L452R, D614G

Eta (B.1.525)

WHO 命名 毒株 货号 抗原 突变位点
Eta B.1.525 40588-V07E19 N A12G, T205I
Eta B.1.525 40589-V08B20 S1+S2 ECD Q52R, A67V, 69/70del, 144del, E484K, D614G, Q677H, F888L
Eta B.1.525 40591-V08H29 S1 Q52R, A67V, 69/70del, 144del, E484K, D614G, Q677H
Eta B.1.525 40591-V08H16 S1 Q677H

Iota (B.1.526)

WHO 命名 毒株 货号 抗原 突变位点
Iota B.1.526 40588-V07E18 N P199L, M234I
Iota B.1.526 40592-V08H112 RBD S477N, E484K
Iota B.1.526 40589-V08B21 S1+S2 ECD L5F, T95I, D253G, S477N, E484K, D614G, A701V
Iota B.1.526 40591-V08H28 S1 L5F, T95I, D253G, S477N, E484K, D614G

Kappa (B.1.617.1)

• Variants in S Protein

• Variants in N Protein

• Recombinant Kappa (B.1.617.1) Variants

WHO 命名 毒株 货号 抗原 突变位点
Kappa B.1.617.1 40589-V49B3-B S1+S2 ECD T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H
Kappa B.1.617.1 40589-V08B15 S1+S2 ECD T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H
Kappa B.1.617.1 40591-V49H1-B S1 T95I, G142D, E154K, L452R, E484Q, D614G, P681R
Kappa B.1.617.1 40591-V08H22 S1 T95I, G142D, E154K, L452R, E484Q, D614G, P681R
Kappa B.1.617/B.1.617.1/B.1.617.3 40592-V02H2 RBD L452R, E484Q
Kappa B.1.617/B.1.617.1/B.1.617.3 40592-V08H88 RBD L452R, E484Q
Kappa B.1.617/B.1.617.1/B.1.617.3 40592-V08H88-B RBD L452R, E484Q
Kappa B.1.617/B.1.617.1/B.1.617.3 40592-V49H-B RBD L452R, E484Q

B.1.617

• Variants in S Protein

• Variants in N Protein

• Recombinant B.1.617 Variants

毒株 货号 抗原 突变位点
B.1.617 40588-V07E16 N D377Y
B.1.617 40588-V07E20 N R203M, D377Y
B.1.617 40589-V08B12 S1+S2 ECD D614G, E154K, E484Q, E1072K, K1073R, L452R, P681R
B.1.617 40589-V08B13 S1+S2 ECD D614G, E154K, E484Q, G142D, H1101D, L452R, P681R, Q1071H
B.1.617 40589-V49B2-B S1+S2 ECD
B.1.617 40591-V08H19 S1 D614G, E154K, E484Q, L452R, P681R
B.1.617 40592-V08H28 RBD L452R
B.1.617 40592-V08H81 RBD E484Q

B.1.617.3

• Variants in S Protein

• Variants in N Protein

• Recombinant B.1.617.3 Variants

毒株 货号 抗原 突变位点
B.1.617.3 40588-V07E30 N P67S, R203M, D377Y
B.1.617.3 40589-V49B5-B S1+S2 ECD T19R, L452R, E484Q, D614G, P681R, D950N, G142D
B.1.617.3 40589-V49B5-B S1+S2 ECD T19R, L452R, E484Q, D614G, P681R, D950N, G142D
B.1.617.3 40589-V08B17 S1+S2 ECD T19R, L452R, E484Q, D614G, P681R, D950N, G142D
B.1.617.3 40591-V08H24 S1 T19R, L452R, E484Q, D614G, P681R, G142D
B.1.617.3 40591-V49H3-B S1 T19R, G142D, L452R, E484Q, D614G, P681R

B.1.618

毒株 货号 抗原 突变位点
B.1.618 40588-V07E28 N G18S, A119S, A217S, M234I, E367Q
B.1.618 40589-V08B14 S1+S2 ECD Y145del, H146del, E484K, D614G
B.1.618 40591-V08H21 S1 H49Y, Y145del, H146del, E484K, D614G

B.1.620

毒株 货号 抗原 突变位点
B.1.620 40589-V08B18 S1+S2 ECD P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H

B.1.2

毒株 货号 抗原 突变位点
B.1.2 40588-V07E22 N P67S, P199L

A.23.1

毒株 货号 抗原 突变位点
A.23.1 40588-V07E23 N S202N

P.2

毒株 货号 抗原 突变位点
P.2 40588-V07E21 N A119S, R203K, G204R, M234I
P.2 40589-V08B19 S1+S2 ECD E484K, F565L, D614G, V1176F
P.2 40591-V08H26 S1 E484K, F565L, D614G, V1176F

P.3

毒株 货号 抗原 突变位点
P.3 40592-V08H111 RBD E484K, N501Y

Mink Variant

毒株 货号 抗原 突变位点
Mink Variant 40591-V08H8 S1 ΔH69/ΔV70, Y453F, D614G
Mink Variant 40592-V08H80 RBD Y453F
Mink Variant 40592-V31H3 RBD Y453F

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货号 抗原 突变位点 标签
40588-V07E12 N P199L His
40588-V07E13 N A220V His
40588-V07E14 N p67S His
40588-V07E15 N M234L His
40589-V08B4 S1+S2 ECD D614G His
40589-V08B5 S1+S2 ECD HV69-70deletion, D614G, D796H His
40591-V08H20 S1 N343Q His
40591-V02H3 S1 D614G Fc
40591-V08H11 S1 N234Q His
40591-V08H3 S1 D614G His
40591-V08H4 S1 A222V, D614G His
40591-V08H6 S1 L18F, D614G His
40591-V08H9 S1 HV69-70deletion, N439K, D614G His
40591-V08H25 S1 P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H His
40592-V08H100 RBD P479L His
40592-V08H101 RBD P479H His
40592-V08H102 RBD N481K His
40592-V08H103 RBD E484A His
40592-V08H104 RBD E484D His
40592-V08H105 RBD N487D His
40592-V08H106 RBD Y449H His
40592-V08H107 RBD G502V His
40592-V08H89 RBD F486A His
40592-V08H92 RBD N440D His
40592-V08H93 RBD F456Y His
40592-V08H94 RBD E471A His
40592-V08H95 RBD E471D His
40592-V08H96 RBD Y473F His
40592-V08H97 RBD A475T His
40592-V08H98 RBD G476A His
40592-V08H99 RBD S477G His
40592-V05H1 RBD V367F mFc
40592-V08H1 RBD V367F His
40592-V08H10 RBD R408I His
40592-V08H11 RBD V341I His
40592-V08H12 RBD Y508H His
40592-V08H14 RBD N439K His
40592-V08H15 RBD V503F His
40592-V08H16 RBD A522V His
40592-V08H19 RBD A372S His
40592-V08H2 RBD N354D His
40592-V08H20 RBD A520S His
40592-V08H21 RBD A522S His
40592-V08H22 RBD D405V, Q414A His
40592-V08H23 RBD Q414E His
40592-V08H24 RBD P384L His
40592-V08H25 RBD A348S His
40592-V08H26 RBD F338L His
40592-V08H27 RBD F377L His
40592-V08H29 RBD P521S His
40592-V08H2-B RBD N354D His
40592-V08H30 RBD T478I His
40592-V08H31 RBD V483I His
40592-V08H32 RBD S359N His
40592-V08H33 RBD K378R His
40592-V08H34 RBD Q409E His
40592-V08H35 RBD I472V His
40592-V08H36 RBD A372T His
40592-V08H37 RBD A344S His
40592-V08H39 RBD A520V His
40592-V08H4 RBD A435S His
40592-V08H40 RBD E406Q His
40592-V08H41 RBD F490S His
40592-V08H42 RBD K378N His
40592-V08H43 RBD N370S His
40592-V08H44 RBD Q414R His
40592-V08H45 RBD S477I His
40592-V08H46 RBD S477N His
40592-V08H47 RBD T385A His
40592-V08H48 RBD T393P His
40592-V08H49 RBD V395I His
40592-V08H5 RBD V483A His
40592-V08H50 RBD A475V His
40592-V08H51 RBD G446V His
40592-V08H52 RBD G485S His
40592-V08H53 RBD G482S His
40592-V08H54 RBD K444R His
40592-V08H55 RBD N440K His
40592-V08H56 RBD E471Q His
40592-V08H57 RBD P479S His
40592-V08H58 RBD A352S His
40592-V08H6 RBD F342L His
40592-V08H62 RBD P337S His
40592-V08H63 RBD P521R His
40592-V08H64 RBD S477R His
40592-V08H68 RBD L455F His
40592-V08H69 RBD K458Q His
40592-V08H7 RBD K458R His
40592-V08H70 RBD N481D His
40592-V08H71 RBD F456L His
40592-V08H72 RBD Y505C His
40592-V08H73 RBD F456E His
40592-V08H74 RBD F486S His
40592-V08H75 RBD N487R His
40592-V08H76 RBD G446S His
40592-V08H78 RBD P499R His
40592-V08H79 RBD V445F His
40592-V08H8 RBD G476S His
40592-V08H83 RBD F490L His
40592-V08H9 RBD W436R His
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