解廷又一文章发表干细胞新成果

【字体: 时间:2008年01月15日 来源:生物通

编辑推荐:

  来自著名的美国密苏里州斯托瓦斯医学研究所(Stowers Institute for Medical Research,生物通注),堪萨斯州大学医学院解剖学与细胞生物学系的研究人员对目前了解得很少的干细胞与其周遍细胞微环境:niche之间的关系进行了描述,进一步揭示了干细胞的奥秘,这一研究成果公布在《Cell Stem Cell》杂志上。

  

生物通报道:来自著名的美国密苏里州斯托瓦斯医学研究所(Stowers Institute for Medical Research,生物通注),堪萨斯州大学医学院解剖学与细胞生物学系的研究人员对目前了解得很少的干细胞与其周遍细胞微环境:niche之间的关系进行了描述,进一步揭示了干细胞的奥秘,这一研究成果公布在《Cell Stem Cell》杂志上。

领导这一研究的是斯托瓦斯医学研究所解廷(简介见后),第一作者为金制钢(Zhigang Jin,音译)和Daniel Kirilly。在07年6月,解廷等人利用果蝇卵巢生殖干细胞(germline stem cells,GSCs)作为研究模型,证明干细胞功能中年龄依赖性的下降和其niche在干细胞整个衰老过程中扮演着十分重要的角色,通过检测了干细胞衰老调控的三个因素,发现并证明衰老过程是受到外在和内在因素调控的。

同时在那篇研究中,研究人员也发现干细胞与niche之间的关联也起到一定作用:强的关联可以延长干细胞的寿命,而降低关联则会增加干细胞衰老。

而在最新的这篇稳文章中,解等人证明分化缺陷型果蝇卵巢生殖干细胞(germline stem cells,GSCs)——与人类癌症干细胞相似,能在niche中竞争“打败”正常干细胞,这主要是通过侵占GSCs的niche空间,并不断增加对黏附性分子E-cadherin的细胞应答,将正常干细胞推出niche。

而且研究小组还发现,突变GSC竞争也需要E-cadherin和正常GSC分裂,并且E-cadherin的不同表达水平可以刺激GSC竞争。

Jin表示,“我们认为这种干细胞竞争机制也许解释了为什么分化干细胞会被niche推挤”,“我们发现干细胞竞争就像一个质量控制体系,确保在niche里只有未分化的干细胞”。

解廷补充道,“这些发现为niche如何严格调控干细胞质量,以及癌症干细胞为了自我增殖如何侵入的新niche提供了重要的信息,而且这些发现也指出了一种将干细胞传递到靶向niche的新策略,这样能通过增加干细胞竞争长时间维持和产生功能性细胞。”
(生物通:张迪)


原文摘要:
Cell Stem Cell, Vol 2, 39-49, 10 January 2008
Differentiation-Defective Stem Cells Outcompete Normal Stem Cells for Niche Occupancy in the Drosophila Ovary
Abstract

附:
中国科学院第四批海外评审专家信息

解 廷(Xie Ting)
性别: 男
出国时间: 1991
最后学位: 博士学位
获得学位的时间: 1996
最后获得学位的单位: Rutgers University,New Jersey, USA
现职单位: 斯德尔(Stowers)医学院
现任职务(英文): Associate Professor
现任职务(中译): 副教授
从事的学科领域: 生命科学与生物技术
专业: 细胞生物学
主要研究方向: 干细胞
现在进行的研究课题: Genetic and molecular studies on the mechanisms controlling stem cell self-renewal,proliferation and differentiation in Drosophila and mice
现单位通讯地址: 1000 East 50 Street Kansas City,MO 64110
传真: 816-916-2029
E-mail: tgx@stowersinstitute.org
所在国家/州/省/城市: 美国 , Kansas City


代表性学术论文/论著:
1.Xiaoqing Song,Marco D.Wong,Eihachiro Kawase,Rongwen Xi,Bee C.Ding,John J.McCarthy and Ting Xie(2004).BMP signals from niche cells directly repress transcription of a differentiation-promoting gene,bag of marbles,in germline stem cells in the Drosophila ovary.Development131,1353-1364.
2.Eihachiro Kawase Marco D.Wong,Bee C.Ding and Ting Xie(2004).Two BMP-like signaling pathways directly control the maintenance of germline stem cells in the Drosophila testis.Development 131,1365-1375.
3.Xiaoqing Song and Ting Xie(2003).The wingless signaling is required for the maintenance and proliferation of somatic stem cells in the Drosophila ovary. Development 103,3259-3268.
4.Chun-Hong Zhu and Ting Xie(2003).Clonal expansion of ovarian germline stem cells during niche formation in Drosophila.Development 130,2579-2588.
5.Xiaoqing Song and Ting Xie(2002).DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary.PNAS,99,14813-14818.
6.Xiaoqing Song,Chun-Hong Zhu,Chuong Doan and Ting Xie(2002).Germline stem cells anchored by adherens junctions in the Drosophila ovary niches.Science 296,1855-1857.
7.Ting Xie and Allan C.Sprading(2001).The Drosophila ovary:an in vivo stem cell system.Stem Cell Biology (Cold Spring Harbor Monograph Series),D.R.Marshak,R.L.Gardner and D.Gottlied,eds.,129-148.
8.Ting Xie and Allan C.Sprading(2000).A niche maintaining germ line stem cells in the Drosophila Ovary.Science 290,328-330.
9.Ting Xie and Allan C.Sprading(1998).decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary.Cell 94,251-260.
10.Ting Xie,Alyce L.Finelli and Richard W.Padgett(1994).The Drosophila saxophone gene:a serine-threonine kinase receptor of TGF-β superfamily.Science 263,1756-1759.

获成果/奖励情况:
1. 2003年,M.R.and Evelyn Hudson Foundation,M.R.and Evelyn Hudson Foundation prize.
2. 1992-1995年,Rutgers University,Busch Predoctoral Fellowship
3. 1984-1987年,Beijing Agricultural University,Highest Academic Honor.

与国内学术交流等情况:
I have visiteed Institute of Zoology of Chinese Academy of Sciences for seminars and have also carried out scientific changes.I have been helping Dr.Duan to train graduate students on stem cell research and have planned to do some collaborative research on stem cells.
I have visited Institute of Microbiology of Chinese Academy of Sciences and College of Life Sciences of Beijing University for scientific exchanges.
Iwas invited to be a plenary speaker in The First International Symposium on Glaucoma(Beijing)in the spring of 2004.
I have been invited to speak in the coming 10 SCBA International Symposium(Beijing).


主要学术贡献创新思想:
I(as a postdoctoral fellow)have first demonstrated that stem cells are controlled by their microenvironments or niches(Xie and Spradling,Science,2000).This niche concept has changed the way scientists study stem cells.
My laboratory has first identified cadherin as "glue"for anchoring stem cells in their niches(Song et al.,Science,2002;Song and Xie,PNAS,2002).It is clear by now that this is a general mechanism for anchoring stem cells in their niche.
Mlaboratory has identified important growth factors that are produced by niche cells and are essential for stem cell self-renewal and proliferation(Song and Cie,Development,2003;Song et al.Development,2004;Kawase ed al.Development,2004).The identification of those growth factors is critical for understanding stem cell biology and using stem cells as therapeutic tools.
My laboratory has recently discovered that multiple stem cells in one niche can derive from one precursor cell(Zhu and Xie,Development,2003).This discovery provides important insight into how empty niches are re-populated in stem cell therapy.

斯托瓦斯研究所(Stowers Institute)

位于密苏里州堪萨斯市,这个60万平方尺的校园里集合了这种先进设施,主要致力于通过进行细胞基本生命过程的研究,寻求尖端技术更有效的预防和治疗疾病。Stowers Institute由Jim Stowers和Virginia Stowers这两位癌症幸存者捐赠的2亿美元资助成立。

 

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