北大禽流感人传人研究取得突破性进展 文章登CID

生物通报道，北京大学基础医学院院长、病理学系主任顾江教授领导课题组在人源性禽流感H5N1复制机制的研究上取得新的进展，相关成果公布在新一期（12月15日）的Clinical Infectious Disease上。

　　

 

 

原文摘要：Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1 Avian Influenza

【Abstract】

The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced real-time polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.