《Nature》推出microRNA文集

　　

生物通报道，microRNA的光芒早在上个世界就开始绽放了，直到目前为止久久不能弥散，甚至更加热门。随着研究的深入，科学家们发现，小小的microRNA参与了几乎所有的生命活动中。近期Nature网站推出microRNA专题文集，将近几年microRNA文章给读者分享。

 

MicroRNA (miRNA) 是一类由内源基因编码的长度约为22 个核苷酸的非编码单链RNA 分子,它们在动植物中参与转录后基因表达调控。包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。

 

据编辑介绍，这次的专题中收录了大量的microRNA的研究性文章，这些paper可加深读者对microRNA的了解，从microRNA生物合成机制，microRNA对基因的调控研究，microRNA对疾病发生发展的影响，到microRNA对生命体的发育以及疾病治疗，本期的专题给了读者丰富了microRNA精神食粮。

 

不仅是小分子非编码RNA可调节基因转录，连miRNA合成过程中的前体RNA也能发挥类似的作用。这方面的代表作非Davis等人2008年在Nature发表的一篇文章末可，他们发现miRNA前体与SMAD共同调控转录后翻译过程。

 

小小的miRNA可抑制基因表达，然而，miRNA降解mRNA和抑制转录的精细机制却一直不为人所知，Selbach等人及Baek等人分别在2008年发表的文章中详细地解析了单个miRNA对目标mRNA降解的过程，通过定量分析了解miRNA的机制。

 

更多的文章读者不妨赶快参看Nature网站的专题文集。很多以前需要付费的文章目前都免费以飨读者。

 

MicroRNAs collection

Letter

A skin microRNA promotes differentiation by repressing 'stemness' — Free access

Rui Yi, Matthew N. Poy, Markus Stoffel & Elaine Fuchs

Nature 452, 225—229 (13 March 2008) doi:10.1038/nature06642

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Article

SMAD proteins control DROSHA–mediated microRNA maturation — Free access

Brandi N. Davis et al.

Nature 454, 56—61 (3 July 2008) doi:10.1038/nature07086

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Article

Widespread changes in protein synthesis induced by microRNAs — Free access

Matthias Selbach et al.

Nature 455, 58—63 (4 September 2008) doi:10.1038/nature07228

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Letter

MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs — Free access

Jennifer L. Umbach et al.

Nature 454, 780—783 (7August 2008) doi:10.1038/nature07103

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Letter

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation — Free access

Yvonne Tay, Jinqiu Zhang, Andrew M. Thomson, Bing Lim & Isidore Rigoutsos

Nature 455, 1124—1128 (23 October 2008) doi:10.1038/nature07299

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Corrigendum

Nature 458, 538 (26 March 2009) doi:10.1038/nature07880

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Article

Endogenous human microRNAs that suppress breast cancer metastasis — Free access

Sohail F. Tavazoie et al.

Nature 451, 147—152 (10 January 2008) doi:10.1038/nature06487

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Letter

MicroRNA–mediated switching of chromatin–remodelling complexes in neural development – Free access

Andrew S. Yoo, Brett T. Staahl, Lei Chen & Gerald R. Crabtree

Nature 460, 642—646 (30 July 2009) doi:10.1038/nature08139

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Erratum

Nature 461, 296 (10 September 2009) doi:10.1038/nature08359

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Letter

LNA–mediated microRNA silencing in non–human primates — Free access

Joacim Elmén et al.

Nature 452, 896—899 (17 April 2008) doi:10.1038/nature06783

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Letter

MicroRNA–21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts — Free access

Thomas Thum et al.

Nature 456, 980—984 (18 December 2008) doi:10.1038/nature07511

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Archive

Letter

Active turnover modulates mature microRNA activity in Caenorhabditis elegans

Saibal Chatterjee & Helge Großhans

Nature 461, 546—549 (24 September 2009) doi:10.1038/nature08349

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Article

miR–145 and miR–143 regulate smooth muscle cell fate and plasticity

Kimberly R. Cordes et al.

Nature 460, 705—710 (6 August 2009) doi:10.1038/nature08195

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Article

Argonaute HITS–CLIP decodes microRNA—mRNA interaction maps

Sung Wook Chi, Julie B. Zang, Aldo Mele & Robert B. Darnell

Nature 460, 479—486 (23 July 2009) doi:10.1038/nature08170

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Letter

Modulation of microRNA processing by p53

Hiroshi I. Suzuki et al.

Nature 460, 529—533 (23 July 2009) doi:10.1038/nature08199

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Letter

The RNA—binding protein KSRP promotes the biogenesis of a subset of microRNAs

Michele Trabucchi et al.

Nature 459, 1010—1014 (18 June 2009) doi:10.1038/nature08025

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Article

Early origins and evolution of microRNAs and Piwi–interacting RNAs in animals

Andrew Grimson et al.

Nature 455, 1193—1197 (30 October 2008) doi:10.1038/nature07415

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Article

The impact of microRNAs on protein output

Daehyun Baek et al.

Nature 455, 64—71 (4 September 2008) doi:10.1038/nature07242

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Letter

Mei–P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

Ralph A. Neumüller et al.

Nature 454, 241—245 (10 July 2008) doi:10.1038/nature07014

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Letter

Regulation of progenitor cell proliferation and granulocyte function by microRNA–223

Jonathan B. Johnnidis et al.

Nature 451, 1125—1129 (28 February 2008) doi:10.1038/nature06607

Abstract | Full Text | PDF | Supplementary Information