北大三聚氰胺综述文章登《Nature》子刊

　　

生物通报道，近期Nature旗下子刊《Kidney Inyerational》在线版刊发了一篇来自北京大学丁洁教授的综述文章，主要解析近期中国奶粉事件中三聚氰胺对婴幼儿健康的影响。文章标题为：Childhood urinary stones induced by melamine-tainted formula: how much we know, how much we don't know。

 

北京大学医学院第一医院副院长丁洁教授，多年来从事小儿肾脏疾病的研究。在2008年三聚氰胺事件中曾参与一线的救治工作，在临床上获得了大量的数据。早先，丁洁教授在国际权威临床刊物《New England Journal of Medicine》发表关于三聚氰胺的临床研究文章，证实三聚氰胺污染奶粉更易致儿童结石（详细了解：

http://www.ebiotrade.com/newsf/2009-2/2009212171022.htm）。

 

但是，对于三聚氰胺，临床和理论的了解有多深？丁洁教授这次在Nature子刊上撰写了一篇迷你综述来谈谈三聚氰胺的情况。

 

通过救治三聚氰胺结石患儿，中国的临床医生获得了大量的临床数据，尤其是关于婴幼儿结石影像学方面的第一手资料。

 

对这些数据分析发现，关于三聚氰胺我们了解的并不很多。还有些问题是我们所不清楚的。综合目前临床上的病例和动物实验，研究小组发现没有明显的证据证实三聚氰胺对动物或是人类的肾脏具有短期，直接的毒性。当然，要判断三聚氰胺的长期毒性还有待临床上长期的追踪观察。目前的研究得出推测性的结论，结石的形成可能与人类的内分泌，新陈代谢以及肾小管的功能有关。

（生物通 小茜）

 

生物通推荐原文检索：

Mini Review

 

Kidney International advance online publication 25 February 2009; doi: 10.1038/ki.2009.30

Childhood urinary stones induced by melamine-tainted formula: how much we know, how much we don't know

Jie Ding

【Abstract】

Through screening, diagnosing, and treating childhood urinary stones induced by melamine-tainted formula, Chinese doctors obtained more experience with the clinical as well as the imaging features of the stones, although there still are many questions regarding melamine-associated stones. By reviewing the earlier reports on animals along with our recent experiences with humans, we concluded that there was no evidence either from animal experiments or from humans to support the direct toxicity of melamine on the kidney, although a feasible follow-up and assessment might be needed. It is also speculated that further studies on the mechanism of stone formation may need to take into account human internal metabolism changes and tubular function.