浙大05女院士最新《Nature》子刊文章

　　

生物通报道，浙江大学医学院附属第一医院中国工程院院士李兰娟以及新加坡纳米技术与生物工程技术学院的Yi-Yan Yang在最新一期的Nature子刊Nature nanotechnology上发表抗微生物研究进展，Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent。

 

抗菌阳离子肽（）因其具有抗多重耐药性细菌的能力而备受关注。大部分的肽结构为α单环结构（α-helices）或是β表格样结构（β-sheet-like），这类的抗菌肽能插入带负电荷的细菌细胞表面，并分解细菌细胞壁。

 

李兰娟等人发现，一类新型的core-shell纳米颗粒具有广谱的抗菌效果，可杀死多种菌类，如真菌。动物试验表明，这类肽能有效杀死耐药性金黄色葡萄球菌。在试验动物兔身上，这类肽能穿越血脑屏障，有效抑制脑内细菌感染。

这些研究结果表明，这些抗菌阳离子肽是一类有应用前景的抗菌药物。

 

（生物通 小茜）

 

生物通推荐原文摘要：

Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent

 

Lihong Liu1,4, Kaijin Xu2, Huaying Wang2, P. K. Jeremy Tan1, Weimin Fan2,3, Subbu S. Venkatraman4, Lanjuan Li2 & Yi-Yan Yang1

 

【Abstract】

Antimicrobial cationic peptides are of interest because they can combat multi-drug-resistant microbes. Most peptides form -helices or -sheet-like structures that can insert into and subsequently disintegrate negatively charged bacterial cell surfaces. Here, we show that a novel class of core–shell nanoparticles formed by self-assembly of an amphiphilic peptide have strong antimicrobial properties against a range of bacteria, yeasts and fungi. The nanoparticles show a high therapeutic index against Staphylococcus aureus infection in mice and are more potent than their unassembled peptide counterparts. Using Staphylococcus aureus-infected meningitis rabbits, we show that the nanoparticles can cross the blood–brain barrier and suppress bacterial growth in infected brains. Taken together, these nanoparticles are promising antimicrobial agents that can be used to treat brain infections and other infectious diseases.