颠覆经典 DNA随细胞组织不同而各异!

【字体: 时间:2009年07月22日 来源:生物通

编辑推荐:

  生物通报道,加拿大Lady Davis Institute for Medical Research,McGill University,University of Sherbrooke的研究者在对主动脉瘤的研究中发现一个独特的遗传学现象,主动脉瘤的致病基因BAK在不同的组织中存在有差异,这一成果发表在《Human Mutation》在线版上。

  

生物通报道,加拿大Lady Davis Institute for Medical ResearchMcGill UniversityUniversity of Sherbrooke的研究者在对主动脉瘤的研究中发现一个独特的遗传学现象,主动脉瘤的致病基因BAK在不同的组织中存在有差异,这一成果发表在《Human Mutation》在线版上。

 

一直以来,无论是在遗传学专业书籍还是人们的常识中,每个细胞中拥有相同的遗传物质DNA是毋庸置疑的。

 

然而,Morris Schweitzer等人在最新的研究中发现了与这一理论相悖的现象。

 

Morris Schweitzer的研究小组在开展对主动脉瘤的遗传研究时发现,主动脉瘤的致病基因BAK在不同的组织中存在有差异(SNP分析),即在血细胞和组织细胞中存在很大的差异。Morris Schweitzer等人对这一结果十分诧异,于是他们又抽取健康人的血细胞和组织细胞,对比BAK基因,令人惊讶的是,结果十分惊人,正常人的两种细胞中的BAK基因也同样存在差异。

 

研究小组提出假设结论,每个细胞的遗传物质DNA可能随着细胞所处的组织环境的不同而有所改变,即并不是每个细胞的DNA都高度一致的。在后天的环境中,DNA发生了变异,存在个体差异。

 

研究者认为,这一结论对疾病的研究具有重要的意义。

(生物通 小茜)

生物通推荐原文检索:

 

BAK1 gene variation and abdominal aortic aneurysms

 

Bruce Gottlieb 1 2 *, Lorraine E. Chalifour 1 3 4 5, Benjamin Mitmaker 6, Nathan Sheiner 6, Daniel Obrand 6, Cherrie Abraham 6, Melissa Meilleur 1, Tomoko Sugahara 1, Ghassan Bkaily 7, Morris Schweitzer 1 4

1Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montréal, Québec, Canada

2Department of Human Genetics, Department of Medicine, McGill University, Montréal, Canada

3Division of Experimental Medicine, McGill University, Montréal, Canada

4Departments of Endocrinology, McGill University, Montréal, Canada

5Bank of Montreal Research Center for the Study of Heart Disease in Woman, McGill University, Montréal, Canada

6Department of Surgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montréal, Canada

7Department of Anatomy and Cell Biology, University of Sherbrooke, Quebec, Canada

 

Abstract

We sought to examine the role of genetics in the multifactorial disease, abdominal aortic aneurysm (AAA), by studying sequence variation in the BAK1 gene (BAK1) that codes for an apoptotic-promoting protein, as chronic apoptosis activation has been linked to AAA development and progression. BAK1 abdominal aorta cDNA from AAA patients and nondiseased individuals were compared with each other, as well as to the BAK1 genomic sequence obtained from matching blood samples. We found specific BAK1 single nucleotide polymorphism (SNP) containing alleles in both aneurysmic (31 cases) and healthy aortic tissue (5 cases) without seeing them in the matching blood samples. These same BAK1 SNPs have been reported, although rarely (average frequency <0.06%), in reference BAK1 DNA sequences. Based on this and other similar observations, we propose a novel hypothesis postulating that multiple variants of genes may preexist in minority forms within specific nondiseased tissues and be selected for, when intra- and/or extracellular conditions change. Therefore, the fact that different BAK1 variants can exist in both diseased and nondiseased AA tissues compared to matching blood samples, together with the rare occurrence of these same SNPs in reference sequences, suggests that selection may be a significant factor in AAA ontogeny. Hum Mutat 30:1-5, 2009. © 2009 Wiley-Liss, Inc.

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