09年中科院候选院士：薛勇彪

　　

生物通编者按：我国的院士评选是从1955年开始的，在正常情况下每两年评选一次。分别由中国科学院和中国工程院评选出中科院院士和工程院院士，合称两院院士。2009年两院院士增选有效候选人分别为296人和449人，其中与生物相关的包括生命科学和医学学部，农业学部等，候选人当中也不乏大家熟悉的一些科学家，为了进一步了解这些科学家，生物通将在评选期间陆续介绍候选人的相关情况，并进行大型网络投票，欢迎大家参与。

薛勇彪 46 植物分子生物学 中国科学院遗传与发育生物学研究所

职称：研究员
职务：遗传与发育生物学研究所所长

1983年，兰州大学生物学系动物学专业理学学士；1986年，中国科学院发育生物学研究所理学硕士；1989年，John Innes Institute
和University of East Anglia博士；1990-1995年，John Innes Centre和University of Oxford博士后。1995-1997年，John Innes Centre
的Sainsbury Laboratory 任Research Scientist。薛勇彪博士系1998年中科院"****"入选者和国家杰出青年科学基金获得者。现任研究所所长、国家973计划"水稻功能基因组学研究"项目首席科学家和《遗传学报》和《遗传》主编，山东农业大学, 北京师范大学，兰州大学和北京大学兼职或客座教授。
1. 金鱼草自交不亲和性的分子机制

　　自交不亲和性是研究植物花粉识别的模式系统。在以茄科植物为代表的配子体自交不亲和植物中，目前的研究结果表明这些植物的自交不亲和性位点－S-位点编码两类不同的基因分别控制花柱和花粉自交不亲和性的表达。花柱基因编码了一类核酸酶称为S-核酸酶，而花粉基因则编码一类新的F-box基因 （S-locus F-box, SLF），共同构成一个S-单倍型（S-Haplotype）控制自交不亲和性的表达。我们实验室以金鱼草为模式系统克隆了SLF家族的第一个成员－AhSLF-S2，并证明它控制了花粉自交不亲和性的表达,并且它编码的蛋白质通过形成一个SCF（Skp1/
Cullin or CDC53/F-box）复合体与S-核酸酶发生作用。与此同时，我们进一步证明泛素/26S蛋白小体介到的蛋白质降解途径特异性的参与了金鱼草的亲和反应。但是，这两类蛋白质如何相互作用产生特异性花粉识别的机理还不清楚。我们实验室目前的主要工作是利用分子遗传，生物化学和细胞生物学等手段，研究这些蛋白质的作用机理以及S-位点的起源和进化机制。


2. 水稻传粉和受精的分子控制

　　传粉和受精是种子形成的重要基础。但是我们对于它的分子机理了解还非常不够。目前我们构建了一个由1万多条非冗余cDNA组成的微阵列，并且获得了水稻传粉和受精相关的基因表达谱，克隆了一批候选基因，正在详细鉴定它们的生物学功能。同时，我们与福建农业大学的吴为人和段远霖合作图位克隆控制水稻开花、花器官发育的关键基因。


3. 棉花纤维发育相关基因的克隆和功能鉴定

　　棉花纤维是胚珠表皮细胞特化的结果。通常30%左右的表皮细胞分化形成棉纤维。目前关于胚珠表皮细胞分化成纤维的分子机理的了解非常有限。利用同源基因克隆的途径，我们分离鉴定了50多个在棉纤维发育早期表达的MYB类转录因子，并发现了一个在纤维发育起始期和伸长期特异表达基因GhMYB109。目前我们正在利用转基因等方法研究该基因在棉纤维发育中的作用机理。


E-mail:[e-mail]



RECENT MAJOR PUBLICATIONS

Research Papers:

1.Li, H., Xue, D., Gao, Z., Yan, M., Xu, W., Xing, Z., Huang, D., Qian, Q., Xue, Y. (2009) A putative lipase gene EXTRA GLUME1 regulates both empty glume fate and spikelet development in rice. Plant J. 57:593-605

2.Zhang, Y., Xu, W., Li, Z., Deng, X., Wu, W., Xue, Y. (2008) F-box protein DOR functions as a novel inhibitory factor for ABA-induced stomatal closure under drought stress in Arabidopsis thaliana. Plant Physiol. 148:2121-2133

3.Xu, S., Deng, Z., Chong, K., Xue, Y., Wang, T. (2008) Dynamic proteomic analysis reveals a switch between central carbon metabolism
and alcoholic fermentation in Oryza sativa filling grains. Plant Physiol. 148:908-925

4.Pu, L., Li, Q., Fan, X., Yang, W., Xue, Y. (2008) A R2R3 MYB transcription factor GhMYB109 is required for cotton fiber development.
Genetics 180:811-820

5.Chen, J., Ding, J., Ouyang, Y., Du, H., Yang, J., Cheng, K., Zhao, J., Qiu, S., Zhang, X., Yao, J., Liu, K., Wang, L., Xu, C., Li, X., Xue, Y., Xia, M., Ji, Q., Lu, J., Xu. M., Zhang, Q. (2008) A tri-allelic system of S5 is a major regulator of the reproductive barrier and compatibility of
indica-japonica hybrids in rice. Proc. Natl. Acad. Sci. USA 105:11436-11441

6.Yang, W., Kong, Z., Omo-Ikerodah, E., Xu, W., Li, Q., Xue, Y. (2008) A calcineurin B-like interacting protein kinase OsCIPK23 functions in
pollination and drought stress responses in rice (Oryza sativa L.). JGG 35:531-543

7.Yang, W., Lai, Y., Li, M., Xu, W., Xue, Y. (2008) A novel C2-domain phospholipid binding protein, OsPBP1, is required for pollen fertility in
rice. Mol Plant 1:770-785

8.Zhang, D., Yang, Q., Ding, Y., Cao, X., Xue, Y., Cheng, Z. (2008) Cytological characterization of the tandem repetitive sequences and their methylation status in Antirrhinum majus genome. Genomics 92:107-114

9.Liu, F., Xu, W., Tan, L., Xue, Y., Sun, C., Su, Z. (2008) Case study for identification of indel-caused alternative expression isoforms in rice
subspecies japonica and indica by integrative genome analysis. Genomics 91:186-194

10.Li, M., Xu, W., Yang, W., Kong, Z., Xue, Y. (2007) Genome-wide gene expression profiling reveals conserved and novel molecular
functions of the stigam in rice (Oryza sativa L.). Plant Physiol. 144:1797-1812
11. Yang, Q., Zhang, D., Li, Q., Cheng, Z., Xue, Y. (2007) Heterochromatic and genetic features are consistent with recombination
suppression of the self-incompatibility (S)-locus in Antirrhinum. Plant J. 51:140-151

12. Wang, X, Zhang, Y., Ma, Q., Zhang, Z., Xu, Z., Xue, Y., Bao, S., Chong, K. (2007) SKB1-mediated symmetric dimethylation of histone
H4R3 controls flowering time in Arabidopsis. EMBO J. 26:1934-1941

13. Dai, S., Chen, T., Chong, K., Xue, Y., Li, S., Wang, T. (2007) Proteomic identification of differentially expressed proteins associated with
pollen germination and tube growth reveals characteristics of germinated Oryza sativa pollen. Mol. Cell. Proteomics 6:207-230

14. Kong, Z., Li, M., Yang, W., Xu, W., Xue, Y. (2006) A novel nuclear-localized CCCH-type zinc finger protein, OsDOS, is involved in delaying
leaf senescence in rice (Oryza sativa L.). Plant Physiol. 141:1376-1388

15. Huang, J., Zhao, L., Yang, Q., Xue, Y. (2006) AhSSK1, a novel SKP1-like protein that interacts with the S-Locus F-box protein.
Plant J. 46:780-793

16. Dai, S., Li, L., Chen, T., Chong, K., Xue, Y., Wang, T. (2006) Proteomic analyses of Oryza sativa mature pollen reveal novel proteins
associated potentially with pollen germination and tube growth. Proteomics 6:2504-2529

17. Dong, L., Wang, L., Zhang, Y., Zhang, Y., Deng, X., Xue, Y. (2006) An auxin-inducible F-box protein CEGENDUO negatively regulates
auxin-mediated lateral root formation in Arabidopsis. Plant Mol Biol. 60:599-616

18.Lan, L., Li, M., Lai, Y., Xu, W., Kong, Z., Ying, K., Han, B., Xue, Y. (2005) Microarray analysis reveals similarities and variations in genetic
programs involved in pollination/fertilization and stress responses in rice (Oryza sativa L.). Plant Mol Biol 59:151-164

19.Wang, Z., Liang, Y., Li, C., Xu, Y., Lan, L., Chen, C., Xu, Z., Xue, Y., Chong, K. (2005) Identification of anther development-related genes by gene expression profiling with a 10-K cDNA microarray in rice (Oryza sativa L.). Plant Mol Biol 58:721-737

20.Causier, B., Castillo, R., Zhou, J., Ingram, R., Xue, Y., Schwarz-Sommer, Z., Davies, B. (2005) Evolution in action：following function in
duplicated floral homeotic genes. Curr. Biol. 15:1508-1512

21.Wang, L., Dong, L., Zhang, Y. E., Zhang, Y., Wu, W., Deng, X.W., Xue, Y. (2005) Genome-wide analysis of S-locus F-box –like genes in
Arabidopsis thaliana. Plant Mol Biol 56:929-945

22.Qiao, H., Wang, F., Zhao, L., Zhou, J., Lai, Z., Zhang, Y., Robbins, T., Y., Xue, Y. (2004) The F-box protein AhSLF-S2 controls the pollen
function of S-RNase-based self-incompatibility. Plant Cell 16:2307-2322

23.Lan, L., Chen, W., Lai, Y., Suo, J., Kong, Z., Li, C., Lu, Y., Zhang, Y., Zhao, X., Zhang, X., Han, B., Cheng, J., Xue, Y. (2004) Monitoring of
gene expression profiles and isolation of candidate genes involved in pollination and fertilization in rice (Oryza sativa L.) using a 10K cDNA
microarray. Plant Mol Biol 54:471-487

24.Qiao, H., Wang, H., Zhao, L., Zhou, J., Huang, J., Zhang, Y., Xue, Y. (2004) The F-box protein AhSLF-S2 physically interacts
with S-RNases that are inhibited by the ubiquitin/26S proteasome pathway of protein degradation during compatible pollination in
Antirrhinum.
Plant Cell 16:582-295

Reviews and Book Chapters:

1.Zhang, Y., Zhao, Z., Xue, Y. (2009) Roles of proteolysis in plant self-incompatibility. Ann. Rev. Plant Biol. 60:21-42

2.Zhang, Q., Li, J., Xue, Y., Han, B., Deng, X. (2008) Rice 2020: A call for an international coordinated effort in rice functional genomics.
Mol Plant 1:715-719

3.Li, C., Zhao, J., Jiang, H., Geng, Y., Dai, Y., Fan, H., Zhang, D., Chen, J., Lu, F., Shi, J., Sun, S., Chen, J., Yang, X., Lu, C., Chen, C., Cheng, Z., Ling, H., Wang, Y., Xue, Y., Li, C. (2008) A snapshot of the Chinese SOL Project. JGG 35: 387-390

4.Zhang, Y., Xue, Y. (2008) Molecular biology of S-RNase-based self-incompatibility. Pages 193-215 in Franklin-Tong, V. E. (ed.)
Self-Incompatibility in Flowering Plants: Evolution, Diversity and Mechanisms, Springer-Verlag

5. Wang, Y., Xue, Y. and Li, J. (2005) Towards molecular breeding and improvement of rice in China. Trends Plant Sci. 10:610-614