惊人发现1918流感、禽流感能诱发可怕后遗症

　　

生物通报道，来自埃默里大学，NIH的科学家在禽流感的研究上取得了最新的进展，相关成果Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration公布在PNAS上。

 

近些年，禽流感疫情不断，危机全球人类的健康，加上与猪流感狭路相逢，给人类的健康带来更大的威胁。

 

禽流感尤其是高致病性禽流感H5N1的致病性比较强，死亡率也比较高。然而，NIH和埃默里大学的科学家最新研究却发现，躲过禽流感致命劫难的患者患帕金森病的几率大大增高，这无疑又是一个不幸的消息。

 

埃默里大学的流行病学家Malu Tansey评价这一文章：这是篇令人兴奋的研究文章。

 

研究者们发现一个现象，经历1918西班牙流感的患者幸存后，在年纪渐长的时候患帕金森的几率比其他没患1918流感的人高。随后，研究人员再度发现，目前在全球流行的禽流感H5N1病毒也具有类似的能力。

 

H5N1病毒对人体具有极强的破坏性，可引发多器官衰竭，更令人担忧的是，这种病毒具有亲神经性，它能感染神经细胞、脑细胞。就动物试验而言，H5N1感染动物常具有明显的神经症状，如脑炎，运动障碍等。

 

如图：

 

箭头所指的就是多巴胺神经元上的沉淀物瘢痕

（生物通 小茜）

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

Haeman Janga,b, David Boltzc, Katharine Sturm-Ramirezc,1, Kennie R. Shepherda,2, Yun Jiaoa, Robert Websterc and Richard J. Smeynea,3

 

Departments of aDevelopmental Neurobiology and

cInfectious Diseases/Virology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678; and

bIntegrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163

【Abstract】

One of the greatest influenza pandemic threats at this time is posed by the highly pathogenic H5N1 avian influenza viruses. To date, 61% of the 433 known human cases of H5N1 infection have proved fatal. Animals infected by H5N1 viruses have demonstrated acute neurological signs ranging from mild encephalitis to motor disturbances to coma. However, no studies have examined the longer-term neurologic consequences of H5N1 infection among surviving hosts. Using the C57BL/6J mouse, a mouse strain that can be infected by the A/Vietnam/1203/04 H5N1 virus without adaptation, we show that this virus travels from the peripheral nervous system into the CNS to higher levels of the neuroaxis. In regions infected by H5N1 virus, we observe activation of microglia and alpha-synuclein phosphorylation and aggregation that persists long after resolution of the infection. We also observe a significant loss of dopaminergic neurons in the substantia nigra pars compacta 60 days after infection. Our results suggest that a pandemic H5N1 pathogen, or other neurotropic influenza virus, could initiate CNS disorders of protein aggregation including Parkinson's and Alzheimer's diseases.