两篇Cell文章证实基因突变动物模型的重要作用

　　

生物通报道：酗酒不但具有伤身的“个人效应”，而且还有制造社会不安的“社会效应”。已经有一些研究显示，酗酒是有遗传因素在其作用的，但是到目前为止这种遗传机制还知之甚少。而改变了酒精敏感性和酒量的动物模型则可能为我们提供有关这种“疾病”发生的分子机制的更多深层信息。

 

在10月6日的Cell杂志上，来自意大利的Nina Offenhauser和美国、瑞典的同事报道说敲除Eps8的小鼠对酒精的一些急性的兴奋性效应的敏感性有所降低，并且小鼠的酒量了有所增加。这其中的原理可能是肌动蛋白动力学状况的变化。这篇文章的图片成为了本期杂志的封面。该图片是用于分析eps8敲除小鼠显型的各种试验方法的集合。

 

也是在本期的Cell杂志上，来自美国加州大学的研究人员发表的另外一篇文章分析了果蝇的一种RhoGAP突变体，其分析结果也支持了在酒精应答过程中肌动蛋白动力学的重要性。（生物通杨遥）

 

以下给出这两篇文章的索引信息

---

Cell, Vol 127, 213-226, 06 October 2006

Article 封面

Increased Ethanol Resistance and Consumption in Eps8 Knockout Mice Correlates with Altered Actin Dynamics

Nina Offenhäuser,¹,⁹, Daniela Castelletti,¹,⁹ Lisa Mapelli,² Blanche Ekalle Soppo,¹ Maria Cristina Regondi,³ Paola Rossi,² Egidio D'Angelo,² Carolina Frassoni,³ Alida Amadeo,⁴ Arianna Tocchetti,¹ Benedetta Pozzi,¹ Andrea Disanza,¹,⁵ Douglas Guarnieri,⁶ Christer Betsholtz,⁷ Giorgio Scita,¹,⁵ Ulrike Heberlein,⁶ and Pier Paolo Di Fiore¹,⁵,⁸,

¹ Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
² Dipartimento di Scienze Fisiologiche e Farmacologiche Cellulari e Molecolari, Università di Pavia, 27100 Pavia, Italy
³ Dipartimento di Epilettologia clinica e Neurofisiologia Sperimentale, Istituto Nazionale Neurologico C. Besta, 20133 Milan, Italy
⁴ Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, 20133 Milan, Italy
⁵ Dipartimento di Oncologia Sperimentale, Istituto Europeo di Oncologia, 20141 Milan, Italy
⁶ Department of Anatomy and Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
⁷ Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
⁸ Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Milano, 20122 Milan, Italy

Corresponding author
Nina Offenhäuser
[e-mail]

Corresponding author
Pier Paolo Di Fiore
[e-mail]

---

Cell, Vol 127, 199-211, 06 October 2006

Article

Distinct Behavioral Responses to Ethanol Are Regulated by Alternate RhoGAP18B Isoforms

Adrian Rothenfluh,¹, Robert J. Threlkeld,¹ Roland J. Bainton,² Linus T.-Y. Tsai,¹,³ Amy W. Lasek,⁴ and Ulrike Heberlein¹,³,⁴,

¹ Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA
² Department of Anesthesia, University of California, San Francisco, San Francisco, CA 94143, USA
³ Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
⁴ Ernest Gallo Clinic and Research Center, Emeryville, CA 94608, USA

Corresponding author
Adrian Rothenfluh
[e-mail]

Corresponding author
Ulrike Heberlein
[e-mail]