复旦校友刘劲松肿瘤研究获重要发现

　　

生物通报道：上皮－基质相互作用在肿瘤的发生和发展过程中起到关键作用。已经知道，与癌症有关的基质能够促进肿瘤的形成。但是，目前人们还不清楚上皮癌细胞如何利用分子信号将正常基质改造成一种肿瘤发生基质。现在，来自得克萨斯州大学M. D. Anderson癌症中心的华人教授刘劲松（JinSong Liu）领导的研究组给出新证据表明趋化因子Gro-1(生长调节致癌基因1)可能是这样的一个信号分子。这项研究的结果公布在近日的《美国科学院院刊》的网络版上。这项研究的领导者刘教授是原上海医科大学（现已并入复旦大学）的校友。

 

（韩国近期重大研究成果快递 ）

 

研究组证实Gro-1的表达能够被RAS活化，并且对细胞的存活和宫颈癌上皮细胞的恶性转变至关重要。研究组惊讶地发现Gro-1是基质纤维原细胞的一种衰老诱导因子，并且这种作用依赖于功能性的p53。由Gro-1诱导的衰老纤维原细胞能够促进肿瘤的生长。

 

研究人员还证实毗邻上皮癌细胞的基质纤维原细胞正在变老。而且Gro-1在宫颈癌中的表达水平明显比正常组织中高，并且也患宫颈癌妇女的血清样本中的Gro-1表达量也比未患宫颈癌妇女血清样本中高。

 

这些发现强有力地证明RAS诱导的Gro-1能够通过诱导纤维原细胞的衰老来重新编排基质微环境，并因此促进肿瘤的形成。因此，Gro-1可能成为一种宫颈癌的治疗靶标和诊断标记物。（生物通杨遥）

Jinsong Liu, M.D., Ph.D.

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Jinsong Liu, M.D., Ph.D.

1983, Shanghai Medical University
1991, Case Western Reserve University

M. D. Anderson Cancer Center
Pathology

Research Interests: Ovarian and breast cancer model; brca1/brca2 in ovarian and breast cancer development; ovarian cancer diagnostic and prognostic markers

The research in my laboratory is directed at understanding of genetic events transforming normal human ovarian and breast epithelial cells into ovarian and breast cancer. A strong focus in my laboratory is to introduce oncogenes into human ovarian or breast epithelial cells in a stepwise manner and create an in vitro model for human ovarian and breast cancer. We are also examining how brca1 or brca2 germline mutation contributes to breast and ovarian cancer development. Second major interest is to identify the novel diagnostic and prognostic markers for human ovarian cancer. We are currently using cDNA microarray to examine the genetic events involved in the transformation from in vitro model and ovarian cancer specimens from ovarian cancer patients. The diagnostic and prognostic markers are compared with ovarian cancer tissue microarray containing hundreds of patients ovarian cancer linked with patients clinical outcome data on a single slide. In this way, we hope to identify early diagnostic markers for ovarian cancer, which can be cured if detected at an early age.

Depending on the student's interests, a tutorial in my laboratory would provide experience with basic cancer mechanism involved in ovarian and breast cancer development or clinical translational research. Our group has been highly productive (see our publication list) and environment for student’s learning is superb.