Kevin White Lab
Department of Human Genetics
The Institute for Genomics and Systems Biology - IGSB
The University of Chicago
920 East 58th Street
Cummings Life Science Center 431
Chicago, IL 60637
My laboratory uses a combination of genomics, computational, and genetic approaches to investigate networks of factors that control gene expression during development and evolution. A major challenge in the "genomic era" of biology is to assemble the thousands of genes and proteins encoded within each genome into comprehensive subsets that specify particular developmental events or physiological processes. Dr. White's lab is approaching this challenge using Drosophila as a model and in the human genome directly.
Hua S, Kallen CB, Dhar R, Baquero MT, Mason CE, Russell BA, Shah PK, Liu J, Khramtsov A, Tretiakova MS, Krausz TN, Olopade OI, Rimm DL, White KP. Genomic Analysis of Estrogen Cascade Reveals Histone Variant H2A.Z Associated with Breast Cancer Progression. Mol Syst Biol. 4:188, 2008.
Y. Gilad, A. Oshlack, G. K. Smyth, T. P. Speed and K. P. White. “Expression profiling in primates reveals a rapid evolution of human transcription factors” Nature 440(7081):242-5, 2006.
S.A. Rifkin, D. Houle, J. Kim and K.P. White. "A mutation accumulation assay reveals extensive capacity for rapid gene expression evolution" Nature 438(7065):220-3, 2005.
V. Stolc, Z. Gauhar, C. Mason et al. “A Gene Expression Map for the Euchromatic Genome of Drosophila melanogaster” Science 306(5696):655-60, 2004.
L. Giot et al. A protein interaction map of Drosophila melanogaster. Science 302(5651):1727-36, 2003.
S.A. Rifkin, J. Kim, K.P. White. Evolution of gene expression in the Drosophila melanogaster subgroup. Nature Genetics 33(2)138-44, 2003.
M.N. Arbeitman et al. Gene expression during the life cycle of Drosophila melanogaster. Science 297:2270-75, 2002.