东京指南是用于诊断急性胆囊炎（Acute Cholecystitis）、评估严重程度并指导治疗的循证国际指南，在 2013 年和 2018 年进行了修订。它综合了多种临床和检查指标。然而，关于东京指南 2018 版的实用性和有效性存在相互矛盾的研究，尚未达成共识。
为评估东京指南 2018 版的诊断标准和严重程度分级在印度一家三级医疗中心回顾性队列中的相关性，研究人员收治了 150 例有右上腹疼痛或疑似急性胆囊炎的连续患者，并按照机构规程进行管理。随后回顾性收集数据，依据东京指南 2018 版进行诊断和严重程度分级，并与病理报告及所接受的治疗进行对比。
最终对 108 例患者的数据进行了分析（平均年龄为 44.68 岁 ±12.62 标准差，女性占 79%），42 例患者被排除在外。83 例患者接受了腹腔镜胆囊切除术（Laparoscopic Cholecystectomy），8 例接受了开腹胆囊切除术（Open Cholecystectomy），4 例进行了胆囊造瘘管置入术（Cholecystostomy-tube Placement），13 例接受了药物治疗。
东京指南 2018 版诊断急性胆囊炎的敏感性为 78.70%。该指南的分级与最终病理报告之间存在显著相关性（p＜0.001，95% 置信区间[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208,209,210,211,212,213,214,215,216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239,240,241,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256,257,258,259,260,261,262,263,264,265,266,267,268,269,270,271,272,273,274,275,276,277,278,279,280,281,282,283,284,285,286,287,288,289,290,291,292,293,294,295,296,297,298,299,300,301,302,303,304,305,306,307,308,309,310,311,312,313,314,315,316,317,318,319,320,321,322,323,324,325,326,327,328,329,330,331,332,333,334,335,336,337,338,339,340,341,342,343,344,345,346,347,348,349,350,351,352,353,354,355,356,357,358,359,360,361,362,363,364,365,366,367,368,369,370,371,372,373,374,375,376,377,378,379,380,381,382,383,384,385,386,387,388,389,390,391,392,393,394,395,396,397,398,399,400,401,402,403,404,405,406,407,408,409,410,411,411,412,413,414,414,415,415,416,416,417,417,418,418,419,419,419,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420,420
