同叶紫檀素的抗HIV-1活性及其作用机制：一种多靶点黄酮类化合物

《Bioorganic Chemistry》：Anti-HIV-1 activity and mechanism of action of homoplantaginin: A multitarget flavonoid compound

　　The content contains information about the anti-HIV activity of a compound called Homo. The materials section describes Homo purchased from TargetMol (China), its chemical structure, CAS number (17,680-84-1), molecular formula (C22H22O11), and molecular weight (462.4 g/mol), along with other reagents used. The results section shows Homo demonstrates moderate but significant anti-HIV-1 activity across multiple cell infection models (TZM-bl/HIV-1, MT-2/HIV-1, and PBMCs/HIV-1), with no significant cytotoxicity and dose-dependent inhibition of HIV-1 replication. The discussion confirms Homo exhibits promising anti-HIV-1 activity with IC50 values in the low-micromolar range and SI above 20. The study was approved by the Ethics Committee of Guangxi Medical University (Approval No. KY20250025), with informed consent obtained from all participants. The research was funded by Guangxi Natural Science Foundation, National Natural Science Foundation, and other institutions. The authors declare no competing interests. The authors are Xin Liu, Qiuzhen Qin, Jie Liu, Yangping Li, Qian Lan, Jiahui Zhang, Xuehua Li, Bingyu Liang, Jiemei Chu, Hao Liang, Bo Zhou, and Li Ye.