PPM1D过表达介导MPN中p53通路失调及PPM1D-HDM2双重抑制耗竭突变克隆的研究

《Blood》：Molecular Consequences and Targeting of PPM1D Overexpression in Myeloproliferative Neoplasms

　　1. PPM1D过表达在MPN患者中很常见，并导致p53介导通路的失调。2. 双重抑制PPM1D和HDM2可导致MPN突变克隆耗竭，同时维持正常造血功能。Md Babu Mia | Christoph Schaniel | Cara Clementelli | Sarah Haines | Malgorzata Olszewska | Joann Arandela | Sebastian Elghaity-beckley | Sophie Klingborg | Zinedine Hoque | Ayman Mohammad | Shwetha Sridhar | Brianna Kelly | Xiaoli Wang | Emmanuel Olivier | Alan Shih | Blake Langlais | Allison J. Cote | Noushin Rahnamay Farnoud | Raajit K. Rampal | Duke Butterfield | Bridget Kelly Marcellino