登陆编号：

10139

性别：

鐢�

国籍：

涓�鍥�

留学国家：

鏃ユ湰鍜岀編鍥�

国外所获学位：

鍗氬＋

专注领域：

鍒嗗瓙鐢熺墿/鐢熺墿鍒惰嵂

求职意向：

鐢熺墿鍒惰嵂鍏�鍙�/鐮斿彂鍜屾妧鏈�鏀�鎸�

期望薪金：

銆�25000

工作地区或城市：

涓婃捣

发表的学术论文：

1. Ye M, Shima F, Muraoka S, Liao J, Okamoto H, Yamamoto M, Tamura A, Yagi N, Ueki T, Kataoka T (2005) Crystal structure of M-Ras reveals a GTP-bound 鈥渙ff鈥� state conformation of Ras family small GTPases J Biol Chem. 280 2005, 21267-31275.
2. Liao J, Shima F, Araki M, Ye M, Muraoka S, Sugimoto T, Kawamura M, Yamamoto N, Tamura A, Kataoka T (2008) Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics. Biochem Biophys Res Commun. 369 2008, 327-33.
3. Ren B, Song K, Parangi S, Jin T, Ye M, Humphreys R, Duquette M, Zhang X, Lawler J,
and Khosravi-Far R. (2009) A double hit to kill tumor and endothelial cells by TRAIL and
anti-angiogenic 3TSR. Cancer Res. 69(9) 2009, 3856-65
4. Ye M. Singh R, Bucur O, Zhu S, Santos M, Rabinovitz I, Wei W, Gao D, Hahn W,
Khosravi-Far R (2009) Protein Phosphatase 2A Reactivates FOXO3a through A Dynamic Interplay with 14-3-3 and AKT. Mol Biol Cell *YE and Singh are equal contribution (Accepted)

主要成就：

4/2002-3/2006: (1). 纭�璁ゅ拰鎻忚堪ras鐨勪綔鐢ㄥ垎瀛愶紝浠ュ強娲诲寲鏈哄埗銆�
(2). M-Ras鐨勭函鍖栧拰缁撴櫠锛屼互鍙婄粨鏅舵瀯閫犵殑娴嬪畾

4/2006-3/2008: 鍩轰簬M-ras鐨勭壒娈婃櫠浣撴瀯閫狅紝鍒╃敤璁＄畻鏈烘ā鎷熷彲浠ュ拰瀹冪壒寮傛�х粨鍚堢殑灏忓垎瀛愬寲鍚堢墿锛屽苟涓斿缓绔嬩綋澶栫瓫閫夋ā鍨嬶紝lead鍖栧悎鐗╁彲浠ョ敤鏉ヨ繘琛屾姉鐧岃嵂鐗╃殑寮�鍙戙��

4/2008-present: (1). 鍒╃敤鑲跨槫缁嗚優鍜岃悿鍏夌礌閰舵姤鍛婄郴缁�(Luciferase Reporter)寤虹珛涓�涓猚ell base鐨勭瓫閫夋ā鍨嬶紝鐢ㄦ潵绛涢�夊彲浠ュ紩璧稦ox3a鐨勮浆褰曟椿鎬у彂鐢熸敼鍙樼殑灏忓垎瀛愬寲鍚堢墿锛屼互姝ゆ潵杈惧埌鎶楃檶鑽�鐗╃殑寮�鍙戙��
(2). PP2a 瀵逛簬Foxo3a鐨勫幓纾烽吀鍖栫殑璋冭妭鏈哄埗