登陆编号：

10599

性别：

鐢�

国籍：

涓�鍥�

留学国家：

鏃ユ湰銆佺編鍥�

国外所获学位：

鍗氬＋鍚�

专注领域：

鐢熺墿鍖栧�︿笌鍒嗗瓙鐢熺墿瀛�

求职意向：

绉戝�︾爺鍙戙�佸疄楠屾妧鏈�銆侀」鐩�绠＄悊绛夊矖浣�

期望薪金：

工作地区或城市：

鍖椾含

发表的学术论文：

Yan Z, Maruyama A, Arakawa T, Fushinobu S, Wakagi T. (2016) Crystal structure of archaeal 2-oxoacid ferredoxin oxidoreductase from Sulfolobus tokodaii. Sci. Rep.6, 33061.
Yan Z, Fushinobu S, Wakagi T. (2014) Four Cys residues in heterodimeric 2-oxoacid:ferredoxin oxidoreductase are required for CoA-dependent oxidative decarboxylation but not for non-oxidative decarboxylation. BBA-Proteins Proteom. 1844 (4), 736-743.
Yan Z, Nam Y, Fushinobu S, Wakagi T (2014). Sulfolobus tokodaii ST2133 is characterized as a thioredoxin reductase-like ferredoxin:NADP+ oxidoreductase. Extremophiles. 18 (1), 99-110.
闂�闇囷紝寰愭槬闇烇紝闂�娴凤紝榄忓穽.娌兼辰绾㈠亣鍗曡優鑿屼笌灏忕悆钘籙STB-01鐨勫叡鍩瑰吇鐮旂┒[J]. 鐜颁唬鍖栧伐. 2009,29锛坰2锛�:172-176.
Li J, Inoue J, Choi JM, Nakamura S, Yan Z, Fushinobu S, Kamada H, Kato H, Hashidume T, Shimizu M, Sato R. (2015) Identification of the flavonoid luteolin as a repressor of the transcription factor hepatocyte nuclear factor 4伪. J. Biol. Chem. 290, 24021-24035.
鍖呮湁闇烇紝闂�闇囷紝闄堢ⅶ闇勶紝闂�娴�.娌兼辰绾㈠亣鍗曡優鑿岀殑鍩瑰吇鍜岀敓浜х暘鑼勭孩绱犵殑浼樺寲鎺у埗[J]. 椋熷搧涓庣敓鐗╂妧鏈�瀛︽姤. 2009,28锛�5锛�:693-697.
鍏崇強鐝婏紝鏉ㄦ檽闈欙紝鍚撮箯椋烇紝闂�闇囷紝闂�娴�.鐭�灏忚娊瀛㈡潌鑿孶STB-06娌绘剤鐧介紶鐑т激鐨勭爺绌�. 鍖诲�﹀姩鐗╅槻鍒讹紝2009,25锛�4锛�:241-243.

主要成就：

鏈�浜虹殑鍗氬＋璇鹃�樻槸2-oxoacid ferredoxin oxidoreductase (OFOR) 鐨勪笁缁寸粨鏅剁粨鏋勫拰鍌�鍖栧弽搴旀満鐞嗙殑鐮旂┒銆侽FOR鏄�涓�绉嶅彲浠ュ偓鍖栦笝閰�閰镐骇涔欓叞杈呴叾A鐨勯叾锛屾�ゅ弽搴斿湪鐪熸牳鐢熺墿涓庡ぇ閮ㄥ垎鐪熺粏鑿屼腑鏄�鐢变笝閰�閰歌劚姘㈤叾澶嶅悎浣撳偓鍖栦骇鐢熶箼閰拌緟閰禔锛屼箼閰拌緟閰禔浠庤�岃繘鍏�TCA (涓夌晶閰�) 寰�鐜�鐨勩�傝�屽湪鏌愪簺鍘屾哀鑿岋紝鏃犵嚎绮掍綋鐪熸牳鐢熺墿锛屽拰鍡滅儹鍙ょ敓鑿屼腑锛屾�ゅ弽搴旀槸鐢監FOR鍌�鍖栫殑銆傚洜姝�OFOR瀵逛簬寰�鐢熺墿鐨勭敓闀垮拰浠ｈ阿鏄�涓�绉嶉潪甯搁噸瑕佺殑閰躲�傛湰浜哄湪鍗氬＋闃舵�碉紝閫氳繃鍚勭�嶅熀鍥犲伐绋嬶紝铔嬬櫧璐ㄥ伐绋嬶紝鐢熺墿鍖栧�﹀拰鐗╃悊鍖栧�︾瓑鎵嬫�碉紝瀵逛簬瓒呭棞鐑�鍙ょ敓鑿孫FOR鐨勫偓鍖栫壒鎬у拰鍙嶅簲鏈虹悊杩涜�屼簡鍏ㄩ潰鑰岄�忓交鐨勭爺绌讹紝骞朵笖杩愮敤褰撲笅绉戠爺棰嗗煙涓绘祦鐨刋灏勭嚎琛嶅皠鎶�鏈�锛屽湪涓栫晫涓婇�栧厛鎴愬姛鐨勮В鏋愬嚭涓�涓狾FOR瀹舵棌鐨勯叾涓夌淮缁撴櫠缁撴瀯锛屽皢璇ラ�嗗煙鐨勭爺绌舵帹杩涗簡閲嶈�佷竴姝� (ps:姝よ�鹃�樻槸涓滀含澶у�﹂叾瀛︾爺绌跺�ら暱骞磋繘琛屼絾鏈�浣滄垚鍔熺殑璇鹃��)銆�
鏈�浜哄湪鍗氬＋闃舵�佃繘琛屼簡鍖呮嫭OFOR涔嬪唴鐨勫�氫釜鍡滅儹鑿屼腑閰剁殑琛ㄨ揪锛岀函鍖栵紝鐑�绋冲畾鎬у拰鍌�鍖栫壒鎬х爺绌躲�備笉浠呭�逛簬铔嬬櫧閰剁殑鍚勭�嶇爺绌跺凡棰囧叿蹇冨緱锛岃�屼笖瀵逛簬鍡滅儹鑿岃泲鐧借川鐨勭儹绋冲畾鎬ф満鐞嗘湁浜嗘繁鍏ヤ簡瑙ｏ紝杩欏�逛簬鎻愰珮鐑�绋冲畾鎬ц泲鐧介叾鐢ㄤ簬宸ヤ笟鐢熶骇鐨勫簲鐢ㄦ綔鍔涘拰鍙戝睍鍓嶆櫙鍏锋湁閲嶈�佸奖鍝嶃�傛�ゅ�栵紝OFOR杩樻槸涓庝汉绫荤柧鐥呯浉鍏崇殑鏌愪簺鍘屾哀鑷寸梾鑿屼腑鐨勯噸瑕佷唬璋㈤叾锛屽洜姝ゅ�逛簬OFOR涓夌淮缁撴瀯鍜屽弽搴旀満鐞嗙殑鐮旂┒锛屾湁鍔╀簬瀵逛簬姝ょ被鐤剧梾鐨勮嵂鐗╄�捐�″拰鑷寸梾鏈虹悊鐨勭爺绌躲��